{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T10:09:57Z","timestamp":1789553397401,"version":"build-2803163510"},"reference-count":58,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,6,16]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">To characterize global trends in stroke and its subtypes attributable to high fasting plasma glucose (FPG) among young adults over the period 1990 to 2023 and to project these trends to 2050.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Using GBD (Global Burden of Disease) 2023 estimates, we quantified deaths, disability\u2010adjusted life years (DALYs), and age\u2010standardized rates of stroke, ischemic stroke (IS), and intracerebral hemorrhage (ICH) attributable to high FPG in adults aged 20 to 44\u2009years, stratified by sex, age group, and sociodemographic index. A Bayesian age\u2013period\u2013cohort model was used to project trends to 2050.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">From 1990 to 2023, global stroke DALYs and deaths attributable to high FPG in young adults increased by 21.9% and 13.5%, while age\u2010standardized DALYs and death rates declined. IS\u2010attributable DALYs and deaths rose by 49% and 31%, versus 7.1% and 6.5% for ICH, with steeper declines in age\u2010standardized ICH rates, indicating a shift from ICH to IS. High and high\u2010middle\u2013sociodemographic index regions showed marked declines in age\u2010standardized rates, whereas middle\u2010to\u2010low\u2013sociodemographic index regions had stable or rising rates and the largest proportional increases in death. By 2050, DALYs from high FPG\u2010related stroke are projected to increase by 66.6% globally, with larger rises for IS than ICH (111.4% versus 40%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Among young adults, the absolute burden of high FPG\u2010attributable stroke is growing, shifting toward IS and increasingly concentrated in women, adults aged 40 to 44\u2009years, and lower\u2013sociodemographic index regions, highlighting the need for earlier, targeted IS prevention in hyperglycemic young adults.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.048400","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T12:16:34Z","timestamp":1781525794000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Global Burden and Projections of Stroke Related to High Fasting Plasma Glucose in Young Adults: A Comparative Analysis From 1990 to 2050"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2490-1415","authenticated-orcid":false,"given":"Jiashuo","family":"Yang","sequence":"first","affiliation":[{"name":"Shengjing Hospital of China Medical University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3630-785X","authenticated-orcid":false,"given":"Yan","family":"Yu","sequence":"additional","affiliation":[{"name":"Shengjing Hospital of China Medical University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6987-7923","authenticated-orcid":false,"given":"Jinlin","family":"Fan","sequence":"additional","affiliation":[{"name":"Shengjing Hospital of China Medical University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2379-1943","authenticated-orcid":false,"given":"Naibo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shengjing Hospital of China Medical University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3333-6147","authenticated-orcid":false,"given":"Honghe","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Health Professions Education Assessment and Reform, China Medical University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7069-8087","authenticated-orcid":false,"given":"Jian","family":"Zheng","sequence":"additional","affiliation":[{"name":"Shengjing Hospital of China Medical University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00642-1"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2022.1520"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(23)00277-6"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.12759"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m3222"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30233-3"},{"key":"e_1_3_2_8_2","volume-title":"Global action plan for the prevention and control of noncommunicable diseases 2013\u20102020","year":"2013","unstructured":"Global action plan for the prevention and control of noncommunicable diseases 2013\u20102020. 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