{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T16:59:30Z","timestamp":1785257970598,"version":"3.55.0"},"reference-count":66,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"14","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,7,21]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Endometriosis has been associated with a higher risk of cardiovascular disease (CVD), but the underlying mechanisms remain incompletely understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Using UK Biobank data, we assessed the relationship between endometriosis and CVD (defined as a composite of fatal and non\u2010fatal coronary heart disease, peripheral artery disease, and stroke), cardiovascular mortality, and all\u2010cause mortality, applying Cox regression analysis while adjusting for conventional and emerging, lifestyle and demographic, and female\u2010specific CVD risk factors. Furthermore, we performed subgroup analysis across age and female\u2010specific factors, and mediation analysis to study the role of hysterectomy and oophorectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">We included 264\u2009740 women without CVD at baseline (median age 57 [25th\u201375th percentile 50\u201363] years; 8194 with endometriosis) from the UK Biobank. During 3\u2009484\u2009788 person\u2010years of follow\u2010up, 22\u2009283 women developed CVD. Endometriosis was associated with an 18% higher risk of CVD (hazard ratio 1.18 [95% CI 1.10\u20131.28]), mainly driven by coronary heart disease (1.24 [1.12\u20131.37]). Conversely, endometriosis was related to a 12% lower risk of all\u2010cause mortality (0.88 [0.80\u20130.98]). The association with cardiovascular mortality was not significant (0.85 [0.63\u20131.13]). Mediation analysis suggested that hysterectomy may partially mediate the association between endometriosis and CVD. Subgroup analyses did not yield significant differences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Endometriosis is associated with a higher risk of CVD, especially coronary heart disease. Mediation analysis suggests that hysterectomy partly explains this association. Whether hysterectomy may proxy endometriosis severity instead of being a true mediator remains to be elucidated. These findings highlight the need for studies that unravel the causal mechanisms linking endometriosis, its treatments, and cardiovascular outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.048454","type":"journal-article","created":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T03:23:01Z","timestamp":1783740181000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Endometriosis and Cardiovascular Disease: Insights From the UK Biobank"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0046-6503","authenticated-orcid":false,"given":"Clara M.","family":"Meijs","sequence":"first","affiliation":[{"name":"Institute of Clinical Epidemiology, Public Health, Health Economics, Medical Statistics and Informatics, Medical University of Innsbruck","place":["Innsbruck, Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6795-937X","authenticated-orcid":false,"given":"Benjamin","family":"Gruenberger","sequence":"additional","affiliation":[{"name":"Institute of Clinical Epidemiology, Public Health, Health Economics, Medical Statistics and Informatics, Medical University of Innsbruck","place":["Innsbruck, Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0346-5412","authenticated-orcid":false,"given":"Sanne A. 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