{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:08:32Z","timestamp":1789013312859,"version":"build-2803163510"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,8,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Heart failure associated with cardiac sarcoidosis (CS) is typically managed using conventional heart failure medications (HFMs). However, their effectiveness in this specific population remains unclear. We aimed to evaluate the association between HFMs and clinical outcomes in patients with CS and left ventricular systolic dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">This post hoc observational analysis used data from the ILLUMINATE\u2010CS (Illustration of the Management and Prognosis of Japanese Patients With Cardiac Sarcoidosis), a retrospective registry of patients diagnosed with CS between 2001 and 2017. Patients with left ventricular ejection fraction &lt;50% were included. Characteristics and outcomes of patients treated with HFMs (\u03b2\u2010blockers, angiotensin\u2010converting enzyme inhibitors, angiotensin receptor blockers, and mineralocorticoid receptor antagonists) at diagnosis were assessed. The primary end point was a composite of all\u2010cause death, hospitalization for heart failure, and documented fatal ventricular arrhythmia events. Propensity score\u2013based overlap weighting analysis was used to balance covariates across the study groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">Of 242 eligible patients with CS, 199 (82%) received at least 1 HFM. The HFM group had significantly lower left ventricular ejection fraction (36% versus 40%) and higher brain natriuretic peptide levels (215 versus 152\u2009pg\/mL) than the non\u2010HFM group. In the unadjusted analysis, the incidence of the primary end point did not differ significantly between the groups (38% versus 37%; hazard ratio [HR]=1.12 [95% CI=0.65\u20131.92]). Overlap weighting analysis showed no significant association between HFM use and the primary end point (HR=0.63 [95% CI=0.32\u20131.23]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Although HFM was commonly used in patients with CS and impaired left ventricular ejection fraction, HFM use at diagnosis was not significantly associated with improved clinical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.048462","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T11:17:55Z","timestamp":1785496675000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Heart Failure Medications and Outcomes in Patients With Cardiac Sarcoidosis and Left Ventricular Systolic Dysfunction: Insights From ILLUMINATE\u2010CS"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0113-1785","authenticated-orcid":false,"given":"Yu","family":"Yamada","sequence":"first","affiliation":[{"name":"University of Tsukuba","place":["Tsukuba, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4549-7770","authenticated-orcid":false,"given":"Kimi","family":"Sato","sequence":"additional","affiliation":[{"name":"University of Tsukuba","place":["Tsukuba, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayoshi","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"University of Tsukuba","place":["Tsukuba, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4671-7667","authenticated-orcid":false,"given":"Takeru","family":"Nabeta","sequence":"additional","affiliation":[{"name":"Kitasato University School of Medicine","place":["Sagamihara, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9630-951X","authenticated-orcid":false,"given":"Yoshihisa","family":"Naruse","sequence":"additional","affiliation":[{"name":"Hamamatsu University School of Medicine","place":["Hamamatsu, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3434-5864","authenticated-orcid":false,"given":"Tatsunori","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"The University of Osaka Graduate School of Medicine","place":["Suita, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2416-5865","authenticated-orcid":false,"given":"Takeshi","family":"Kitai","sequence":"additional","affiliation":[{"name":"National Cerebral and Cardiovascular Center","place":["Suita, Japan"]},{"name":"Kobe City Medical Center General Hospital","place":["Kobe, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3273-459X","authenticated-orcid":false,"given":"Kenji","family":"Yoshioka","sequence":"additional","affiliation":[{"name":"Kameda Medical Center","place":["Kamogawa, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1642-7039","authenticated-orcid":false,"given":"Hidekazu","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Kobe University Graduate School of Medicine","place":["Kobe, Japan"]},{"name":"Kindai University Faculty of Medicine","place":["Osaka, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0931-3188","authenticated-orcid":false,"given":"Ryota","family":"Morimoto","sequence":"additional","affiliation":[{"name":"Nagoya University Graduate School of Medicine","place":["Nagoya, 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