{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:52:52Z","timestamp":1791355972879,"version":"4.3.1"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"19","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,10,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Most evidence for transcatheter aortic valve replacement (TAVR) for valve\u2010in\u2010valve procedures comes from balloon\u2010expandable and supra\u2010annular self\u2010expanding valves. However, data on intra\u2010annular self\u2010expanding valves remain limited. The objectives of this registry were to evaluate the short\u2010 and midterm outcomes of ViV\u2010TAVR using the intra\u2010annular self\u2010expanding valve Navitor platform in a real\u2010world setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">The NAViV (Navitor Valve\u2010in\u2010Valve) registry is a retrospective, multicenter study that included 200 patients who underwent valve\u2010in\u2010valve TAVR with the Portico\/Navitor systems. The primary end point was 30\u2010day device success. Secondary outcomes included intraprocedural technical success, early safety, and all\u2010cause death and major adverse events at 2\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">The cohort had a high\u2010risk profile and a high prevalence of small surgical bioprostheses (internal diameter \u226421\u2009mm in 86% of the patients). Technical success was achieved in 96%, with an in\u2010hospital mortality rate of 2% and early safety at 30\u2009days of 84%. Mean residual gradients after TAVR were low (14 [interquartile range, 10\u201320] mm\u2009Hg), and residual significant aortic regurgitation was rare (1%). Device success was 73.5%, with high residual gradients (\u226520\u2009mm\u2009Hg) being the main reason for device failure. Two\u2010year survival and major adverse events were 85.6% and 69.8%, respectively; with low residual gradients and baseline significant AR being independently associated with higher survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Valve\u2010in\u2010valve TAVR using the Portico\/Navitor intra\u2010annular self\u2010expanding valve demonstrates a favorable procedural safety profile, sustained valve performance, and encouraging midterm survival in intermediate\u2010 and high\u2010risk populations. Larger and comparative studies are warranted to confirm these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.048519","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:14:22Z","timestamp":1790680462000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Outcomes and Valve Performance of Intra\u2010Annular Self\u2010Expanding Transcatheter Aortic Valve in Valve\u2010in\u2010Valve Procedures: Insights From the NAViV Registry"],"prefix":"10.1161","volume":"15","author":[{"given":"Jorge","family":"Chavez","sequence":"first","affiliation":[{"name":"Cardiovascular Institute, Hospital Cl\u00ednico San Carlos, Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdISSC)","place":["Madrid, 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Santa Creu i Sant Pau, Institut de Recerca Sant Pau, CIBERCV, ISCIII","place":["Barcelona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Berenguer","sequence":"additional","affiliation":[{"name":"Consorcio Hospital General Universitario de Valencia","place":["Valencia, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4507-675X","authenticated-orcid":false,"given":"Alba Abril","family":"Molina","sequence":"additional","affiliation":[{"name":"Hospital Universitario Virgen del Rocio","place":["Sevilla, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0657-4457","authenticated-orcid":false,"given":"Jose Ram\u00f3n","family":"Lopez\u2010Minguez","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Badajoz, Universidad de Extremadura","place":["Badajoz, 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