{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:52:50Z","timestamp":1791355970029,"version":"4.3.1"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"19","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,10,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Deoxycholic acid (DCA) and its conjugates glycodeoxycholic acid (GDCA), taurodeoxycholic acid, and 23\u2010nordeoxycholic acid (NorDCA) were implicated in anti\u2010inflammation and energy metabolism, but their prognostic values in ischemic stroke remained unclear. We aimed to investigate the associations of plasma DCA and its conjugates with outcomes after ischemic stroke in a multicenter prognostic cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Our multicenter prognostic cohort study included 3405 Chinese patients with hypertensive stroke from the China Antihypertensive Trial in Acute Ischemic Stroke. The primary outcome was a composite outcome of death and major disability (modified Rankin Scale score, 3\u20136) at 3\u2009months after ischemic stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      After adjustment for age, sex, and other important covariates, elevated plasma DCA (odds ratio [OR], 0.65 [95% CI, 0.53\u20130.80]), GDCA (OR, 0.76 [95% CI, 0.61\u20130.93]), and NorDCA (OR, 0.73 [95% CI, 0.59\u20130.89]) were associated with a decreased risk of primary outcome when 2 extreme tertiles were compared. Multiple\u2010adjusted spline regression model showed linear associations of DCA, GDCA, and NorDCA with the primary outcome (all\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      value for linearity&lt;0.05). Adding DCA, GDCA, NorDCA, or DCA metabolite score to conventional prognostic factors significantly improved the risk reclassification for the primary outcome, as evidenced by net reclassification improvement and integrated discrimination index (all\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">High DCA, GDCA, and NorDCA at baseline were associated with decreased risks of adverse outcomes at 3\u2009months after ischemic stroke, indicating that DCA, GDCA, and NorDCA might be implicated in the development of ischemic stroke and could be valuable intervention targets for ischemic stroke.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.048565","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T13:35:53Z","timestamp":1789738553000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Associations of Plasma Deoxycholic Acid and Its Conjugates With the Clinical Outcomes After Ischemic Stroke"],"prefix":"10.1161","volume":"15","author":[{"given":"Xiaoli","family":"Qin","sequence":"first","affiliation":[{"name":"Suzhou Medical College of Soochow University","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Yu","sequence":"additional","affiliation":[{"name":"Suzhou Medical College of Soochow University","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beiping","family":"Song","sequence":"additional","affiliation":[{"name":"Suzhou Medical College of Soochow University","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawen","family":"Fei","sequence":"additional","affiliation":[{"name":"Suzhou Medical College of Soochow University","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8769-9487","authenticated-orcid":false,"given":"Lingxiang","family":"Ye","sequence":"additional","affiliation":[{"name":"Suzhou Medical College of Soochow University","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhen","family":"Guo","sequence":"additional","affiliation":[{"name":"Suzhou Medical College of Soochow University","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4537-0705","authenticated-orcid":false,"given":"Daoxia","family":"Guo","sequence":"additional","affiliation":[{"name":"Suzhou Medical College of Soochow University","place":["Suzhou, China"]},{"name":"Suzhou Medical College of Soochow University","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5883-0416","authenticated-orcid":false,"given":"Mengyao","family":"Shi","sequence":"additional","affiliation":[{"name":"Suzhou Medical College of Soochow University","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aili","family":"Wang","sequence":"additional","affiliation":[{"name":"Suzhou Medical College of Soochow University","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9278-1622","authenticated-orcid":false,"given":"Tan","family":"Xu","sequence":"additional","affiliation":[{"name":"Suzhou Medical College of Soochow University","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6188-3490","authenticated-orcid":false,"given":"Yonghong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Suzhou Medical College of Soochow University","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5500-0014","authenticated-orcid":false,"given":"Zhengbao","family":"Zhu","sequence":"additional","affiliation":[{"name":"Suzhou Medical College of Soochow University","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(24)00369-7"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2024.102758"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000158"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-025-02485-x"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2025.2462261"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25797"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0509-0"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00534.2018"},{"key":"e_1_3_2_10_2","article-title":"Mechanism of bile acid in regulating platelet function and thrombotic diseases","volume":"11","author":"Zhou X","year":"2024","unstructured":"Zhou X, Zhou X, Zhang Z, Zhu R, Lu M, Lv K, Fang C, Ming Z, Cheng Z, Hu Y. Mechanism of bile acid in regulating platelet function and thrombotic diseases. Adv Sci (Weinheim, Baden\u2010Wurttemberg, Germany). 2024;11:e2401683.","journal-title":"Adv Sci (Weinheim, Baden\u2010Wurttemberg, Germany)"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s44161-025-00637-x"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2020.10.014"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41522-024-00585-7"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddad174"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.282543"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.20.7.864"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.24.1.35"},{"key":"e_1_3_2_18_2","first-page":"390","article-title":"Chinese guidelines on prevention and treatment of dyslipidemia in adults","volume":"35","year":"2007","unstructured":"Chinese guidelines on prevention and treatment of dyslipidemia in adults. Zhonghua Xin Xue Guan Bing Za Zhi. 2007;35:390\u2013419.","journal-title":"Zhonghua Xin Xue Guan Bing Za Zhi"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-018-1032-5"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318259e221"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2929"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.3390\/biology14070802"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2024.2323236"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom14030305"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-6-11"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1042\/BST20130279"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41522-023-00374-8"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.005380"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.125.048565","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:24:39Z","timestamp":1791354279000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.125.048565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,6]]},"references-count":27,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2026,10,6]]}},"alternative-id":["10.1161\/JAHA.125.048565"],"URL":"https:\/\/doi.org\/10.1161\/jaha.125.048565","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,6]]},"assertion":[{"value":"2025-12-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e048565"}}