{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:08:43Z","timestamp":1789013323842,"version":"build-2803163510"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,8,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">In August 2025, the American Heart Association and American College of Cardiology released updated hypertension guidelines. Under the new guidelines, therapy is advised at blood pressure \u2265130\/80\u2009mm\u2009Hg in adults with diabetes, chronic kidney disease, or a Predicting Risk of Cardiovascular Disease Events\u2010estimated 10\u2010year cardiovascular disease risk \u22657.5%. The long\u2010term population\u2010level changes following these guidelines remains uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We analyzed NHANES (National Health and Nutrition Examination Survey) 2009 to 2018 data linked to mortality through 2019. Hypertensive adults without baseline cardiovascular disease were included. Treatment eligibility was defined using guideline criteria. Cox models estimated associations between antihypertensive therapy and all\u2010cause and cardiovascular mortality. Simulation analyses projected lives saved under full and partial treatment uptake.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">The weighted cohort represented 81.0 million US adults with hypertension. Of these, 22.8 million (28%) were guideline eligible for therapy; 13.1 million (57%) were treated, and 9.7 million (43%) remained untreated. Antihypertensive therapy was associated with a 23% reduction in all\u2010cause mortality (hazard ratio [HR], 0.77 [95% CI, 0.63\u20130.94]) and 50% reduction in cardiovascular mortality (HR, 0.50 [95% CI, 0.36\u20130.68]). At 10\u2009years, universal treatment of eligible but untreated adults was projected to prevent ~200\u2009900 all\u2010cause and\u2009~\u2009162\u2009600 cardiovascular deaths. Benefits were greatest in adults with diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">In this nationally representative cohort, nearly 1 in 3 US adults with hypertension were newly eligible for therapy under the guideline, yet &gt;2 in 5 remained untreated. Extending treatment to all eligible adults could prevent &gt;200\u2009000 all\u2010cause and 160\u2009000 cardiovascular deaths over the next decade.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.048616","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:33:26Z","timestamp":1785324806000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Population\u2010Level 10\u2010Year Implications of the New 2025 American Heart Association\/American College of Cardiology Hypertension Guideline Recommendations for Primary Prevention in the United States: A NHANES\u2010Based Cohort Study (2009\u20132018)"],"prefix":"10.1161","volume":"15","author":[{"given":"Mustafa","family":"Al\u2010jarshawi","sequence":"first","affiliation":[{"name":"University of Manchester","place":["Manchester, UK"]},{"name":"Keele University","place":["Keele, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9485-0652","authenticated-orcid":false,"given":"Sripal","family":"Bangalore","sequence":"additional","affiliation":[{"name":"New York University Langone Medical Center","place":["New York, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8464-1080","authenticated-orcid":false,"given":"Harindra C.","family":"Wijeysundera","sequence":"additional","affiliation":[{"name":"University of Toronto","place":["Toronto, Canada"]},{"name":"The Institute for Clinical Evaluative Sciences (ICES)","place":["Toronto, Canada"]},{"name":"Temerty Faculty of Medicine University of Toronto","place":["Toronto, Canada"]},{"name":"University of Toronto","place":["Toronto, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0640-0430","authenticated-orcid":false,"given":"Nicholas WS","family":"Chew","sequence":"additional","affiliation":[{"name":"National University Health System","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3381-605X","authenticated-orcid":false,"given":"Elad","family":"Asher","sequence":"additional","affiliation":[{"name":"Keele University","place":["Keele, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6435-0411","authenticated-orcid":false,"given":"Anastasia S.","family":"Mihailidou","sequence":"additional","affiliation":[{"name":"Royal North Shore Hospital and Kolling Insitute","place":["St Leonards, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8370-4569","authenticated-orcid":false,"given":"Harriette G.C.","family":"Van Spall","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, McMaster University, and Population Health Research Institute","place":["Hamilton, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9241-8890","authenticated-orcid":false,"given":"Mamas A.","family":"Mamas","sequence":"additional","affiliation":[{"name":"Keele University","place":["Keele, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.018912"},{"key":"e_1_3_1_3_2","unstructured":"High stakes\u2010turning evidence into action Global report on hypertension 2025."},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(25)00055-8"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/ARCHINTE.159.18.2206"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYP.0000000000000249"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.JACC.2025.07.010"},{"key":"e_1_3_1_8_2","first-page":"1","article-title":"The National Health and Nutrition Examination Survey: sample design, 1999\u20102006","volume":"155","author":"Curtin LR","year":"2012","unstructured":"Curtin LR, Mohadjer LK, Dohrmann SM, Montaquila JM, Kruszan\u2010Moran D, Mirel LB, Carroll MD, Hirsch R, Schober S, Johnson CL. The National Health and Nutrition Examination Survey: sample design, 1999\u20102006. Vital Health Stat 2. 2012;155:1\u201339.","journal-title":"Vital Health Stat 2"},{"key":"e_1_3_1_9_2","unstructured":"Centers for Disease Control and Prevention . ANALYTIC AND REPORTING GUIDELINES The National Health and Nutrition Examination Survey (NHANES) NHANES Analytic and Reporting Guidelines. 2006 Accessed January 4 2025. http:\/\/www.cdc.gov\/nchs\/data\/nhanes\/guidelines1.pdf."},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.067626"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.125.25465"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","unstructured":"Jones DW Taler SJ Ferdinand KC. Blood Pressure Management Guideline Development A Professional and Personal Journey. doi: 10.1016\/j.jacc.2025.08.008.","DOI":"10.1016\/j.jacc.2025.08.008"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001191"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/JAMA.2024.12537"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.124.038915"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.124.22998\/FORMAT\/EPUB"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMOA1511939"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.034322"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(91)90432-H"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.2337\/DIACARE.16.2.434"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajkd.2003.07.015"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.592733"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01225-8"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1001\/JAMA.288.23.2981"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/EHJOPEN\/OEAF117"},{"key":"e_1_3_1_26_2","unstructured":"High Blood Pressure Facts|High Blood Pressure|CDC. Accessed September 27 2025. https:\/\/www.cdc.gov\/high\u2010blood\u2010pressure\/data\u2010research\/facts\u2010stats\/index.html."},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.JACC.2025.08.011"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001355"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.124.038644"},{"key":"e_1_3_1_30_2","unstructured":"Prior HHS Poverty Guidelines and Federal Register References | ASPE. Accessed May 10 2025. https:\/\/aspe.hhs.gov\/topics\/poverty\u2010economic\u2010mobility\/poverty\u2010guidelines\/prior\u2010hhs\u2010poverty\u2010guidelines\u2010federal\u2010register\u2010references."},{"key":"#cr-split#-e_1_3_1_31_2.1","unstructured":"US Department of Health and Human Service . Federal Register. 1995 Poverty income guidelines"},{"key":"#cr-split#-e_1_3_1_31_2.2","unstructured":"annual revision. Accessed May 10 2025. https:\/\/aspe.hhs.gov\/sites\/default\/files\/2021\u201007\/hhs\u2010poverty\u2010guidelines\u2010fed\u2010reg\u20101995.pdf."},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2102953"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.125.048616","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:42:03Z","timestamp":1789011723000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.125.048616"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,4]]},"references-count":32,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2026,8,4]]}},"alternative-id":["10.1161\/JAHA.125.048616"],"URL":"https:\/\/doi.org\/10.1161\/jaha.125.048616","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,4]]},"assertion":[{"value":"2025-12-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e048616"}}