{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:08:43Z","timestamp":1789013323699,"version":"build-2803163510"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,8,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Systemic inflammation is increasingly recognized as an important contributor to cardiovascular outcomes. High\u2010sensitivity CRP (C\u2010reactive protein) is an established biomarker, but its prognostic value after mitral transcatheter edge\u2010to\u2010edge repair remains unclear. Clinical parameters such as body temperature may also reflect systemic inflammation; however, their prognostic role in this setting is uncertain. We sought to investigate the association between baseline inflammation makers and long\u2010term outcomes in patients undergoing mitral transcatheter edge\u2010to\u2010edge repair.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We analyzed 3511 patients from the OCEAN (Optimized Catheter Valvular Intervention)\u2010Mitral registry with available CRP, categorized by Centers for Disease Control and Prevention\/American Heart Association cutoffs: &lt;1.0\u2009mg\/L (n=1216), 1.0\u20133.0\u2009mg\/L (n=988), and &gt;3.0\u2009mg\/L (n=1307). Body temperature was also assessed as an exploratory inflammatory marker.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">During a median follow\u2010up of 13 (interquartile range, 10\u201326) months, 826 deaths and 911 composite event of cardiovascular death or hospitalization for heart failure were observed. In multivariable models, both CRP and body temperature were associated with higher risk of death (CRP: hazard ratio [HR], 1.98 [95% CI, 1.63\u20132.40]; and body temperature: HR, 1.49 [95% CI, 1.25\u20131.78]). Patients with both elevated CRP (&gt;3.0\u2009mg\/L) and high temperature (\u226537.0 \u00b0C) had the highest risk. Sequential Cox analyses showed an incremental value of CRP beyond clinical, laboratory, and echocardiographic variables. The prognostic effect was most pronounced in patients without preprocedural inotrope use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Elevated CRP is an independent and incremental predictor of death and heart failure outcomes after mitral transcatheter edge\u2010to\u2010edge repair, with its prognostic impact amplified by higher body temperature. These findings highlight the importance of incorporating systemic inflammation into risk stratification for structural heart interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Registration<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.umin.ac.jp\/ctr\/\">https:\/\/www.umin.ac.jp\/ctr\/<\/jats:ext-link>\n                      ; Unique identifier: UMIN\u2010ID: UMIN000023653.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.048726","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T11:49:35Z","timestamp":1785239375000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Systemic Inflammation and Outcomes After Mitral Edge\u2010to\u2010Edge Repair: Insights From the OCEAN\u2010Mitral Registry"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8132-7173","authenticated-orcid":false,"given":"Kazunori","family":"Omote","sequence":"first","affiliation":[{"name":"Hokkaido Cardiovascular Hospital","place":["Sapporo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5210-6382","authenticated-orcid":false,"given":"Masanori","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Toyohashi Heart Center","place":["Toyohashi, Japan"]},{"name":"Nagoya Heart Center","place":["Nagoya, Japan"]},{"name":"Gifu Heart Center","place":["Gifu, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9446-9963","authenticated-orcid":false,"given":"Atsushi","family":"Sugiura","sequence":"additional","affiliation":[{"name":"Nagoya Heart Center","place":["Nagoya, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuro","family":"Shimura","sequence":"additional","affiliation":[{"name":"Gifu Heart Center","place":["Gifu, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4794-7843","authenticated-orcid":false,"given":"Shunsuke","family":"Kubo","sequence":"additional","affiliation":[{"name":"Kurashiki Central Hospital","place":["Kurashiki, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4542-5809","authenticated-orcid":false,"given":"Yuki","family":"Izumi","sequence":"additional","affiliation":[{"name":"Sakakibara Heart Institute","place":["Tokyo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2057-109X","authenticated-orcid":false,"given":"Mike","family":"Saji","sequence":"additional","affiliation":[{"name":"Toho University Faculty of Medicine","place":["Tokyo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2102-033X","authenticated-orcid":false,"given":"Masahiko","family":"Asami","sequence":"additional","affiliation":[{"name":"Mitsui Memorial Hospital","place":["Tokyo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1931-1012","authenticated-orcid":false,"given":"Yusuke","family":"Enta","sequence":"additional","affiliation":[{"name":"Sendai Kosei Hospital","place":["Sendai, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4764-8205","authenticated-orcid":false,"given":"Shinichi","family":"Shirai","sequence":"additional","affiliation":[{"name":"Kokura Memorial Hospital","place":["Kitakyushu, 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