{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T13:53:52Z","timestamp":1781790832843,"version":"3.54.5"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,6,2]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Transcatheter aortic valve replacement (TAVR) improves symptoms and survival in patients with severe aortic stenosis, yet the incidence and prognostic significance of early postprocedural heart failure (HF) hospitalization remain incompletely characterized. Our objective is to determine the incidence, clinical characteristics, prognostic implications, and predictors of early HF hospitalization after TAVR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Using the Medicare Provider Analysis and Review database, we identified fee\u2010for\u2010service beneficiaries \u226565\u2009years who underwent TAVR between January 1, 2017, and November 30, 2021. Early post\u2010TAVR HF hospitalization was defined as at least 1 HF readmission occurring between 31 and 365\u2009days after the index procedure. Patients were classified according to the presence or absence of HF hospitalization during this period. Cox proportional hazards models were used to evaluate the association with mortality after adjustment for clinical, procedural, and sociodemographic factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Among 233\u2009309 patients undergoing TAVR, 45\u2009502 (19.5%) experienced HF hospitalization within 1\u2009year. Patients with early HF hospitalization had markedly higher mortality compared with those without HF hospitalization, including 1\u2010year mortality (43.8% versus 3.6%) and 5\u2010year mortality (80.6% versus 41.0%) (log\u2010rank\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001). After multivariable adjustment, early HF hospitalization was strongly associated with increased mortality (adjusted hazard ratio [HR], 3.17 [95% CI, 3.11\u20133.22]). The strongest predictors of early HF hospitalization were advanced cardiac damage stage (adjusted\u2010subdistribution HR, 1.95 [95% CI, 1.88\u20132.02]) and high\u2010risk frailty (adjusted\u2010subdistribution HR, 1.65 [95% CI, 1.58\u20131.72]), with graded risk across stages.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Nearly 1 in 5 older adults undergoing TAVR experience early HF hospitalization, which is associated with markedly increased short\u2010 and long\u2010term mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.048751","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T10:45:05Z","timestamp":1779705905000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Early Postrranscatheter Aortic Valve Replacement Heart Failure Hospitalization and Outcomes in Older Patients"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0303-9619","authenticated-orcid":false,"given":"Harun","family":"Kundi","sequence":"first","affiliation":[{"name":"Cardiovascular Research Foundation","place":["New York, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2002-7492","authenticated-orcid":false,"given":"Martin","family":"Leon","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Foundation","place":["New York, USA"]},{"name":"Columbia\u2010Presbyterian Medical Center","place":["New York, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9163-724X","authenticated-orcid":false,"given":"David J.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Foundation","place":["New York, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4701-6234","authenticated-orcid":false,"given":"Alexandra","family":"Popma","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Foundation","place":["New York, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8304-8194","authenticated-orcid":false,"given":"Yukari","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Foundation","place":["New York, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4155-4451","authenticated-orcid":false,"given":"Bjorn","family":"Redfors","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Foundation","place":["New York, USA"]},{"name":"Weill\u2010Cornell University Medical Center, New York","place":["New York, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren S.","family":"Ranard","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Foundation","place":["New York, USA"]},{"name":"Columbia\u2010Presbyterian Medical Center","place":["New York, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0430-3020","authenticated-orcid":false,"given":"Maria C.","family":"Alu","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Foundation","place":["New York, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5659-9168","authenticated-orcid":false,"given":"Julia B.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Foundation","place":["New York, 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