{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T07:03:35Z","timestamp":1789715015054,"version":"4.0.1"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,5,19]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Venetoclax, a potent B\u2010cell leukemia\/lymphoma\u20102 inhibitor, is an antineoplastic agent used in various hematologic malignancies, including acute myeloid leukemia (AML). The aim of the study is to evaluate the incidence, risk factors, and outcomes of major adverse cardiac events (MACEs) among patients with newly diagnosed AML receiving venetoclax\u2010based therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We conducted a retrospective, single\u2010center cohort study of 214 patients with newly diagnosed AML treated with venetoclax. MACE was defined as a composite of new\u2010onset heart failure, heart failure exacerbation requiring hospitalization, myocardial infarction\/coronary revascularization, or stroke\/transient ischemic attack during active venetoclax\u2010based therapy. The Fine\u2013Gray subdistribution hazard model determined the association between baseline clinical characteristics and MACEs, with noncardiovascular death as a competing risk. A Cox proportional hazard model determined the association between time\u2010dependent MACEs and overall survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Among 214 patients (mean age, 71.5\u2009years; 41% women), MACEs occurred in 14 (6.5%) patients. Patients with non\u2013de novo (secondary \/treatment\u2010related) AML had a higher incidence of MACEs compared with de novo AML (85.7% versus 14.3%; subdistribution hazard ratio [HR], 7.1 [95% CI, 1.5\u201333];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.01). Time\u2010dependent MACE was independently associated with inferior overall survival (adjusted HR, 2.75 [95% CI, 1.41\u20135.35]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">In conclusion, MACE is a clinically significant event that occurs in 6.5% of patients with AML treated with venetoclax and is a higher\u2010risk event for patients with secondary AML or treatment\u2010related AML.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.048790","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T09:13:11Z","timestamp":1778058791000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Cardiovascular Adverse Events During Venetoclax\u2010Based Treatment in Acute Myeloid Leukemia"],"prefix":"10.1161","volume":"15","author":[{"given":"Sruthi","family":"Selvakumar","sequence":"first","affiliation":[{"name":"University of South Florida Morsani College of Medicine","place":["Tampa, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanath","family":"Shetty","sequence":"additional","affiliation":[{"name":"Moffitt Cancer Center and Research Institute","place":["Tampa, USA"]},{"name":"University of South Florida Morsani College of Medicine","place":["Tampa, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7523-6886","authenticated-orcid":false,"given":"Alexis Behne","family":"Sharma","sequence":"additional","affiliation":[{"name":"University of South Florida","place":["Tampa, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5989-1117","authenticated-orcid":false,"given":"Fatima 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