{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T07:03:36Z","timestamp":1789715016974,"version":"4.0.1"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,5,19]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Cerebral amyloid angiopathy (CAA), a cerebral small vessel disease characterized by vascular amyloid deposition, presents with heterogeneous imaging features, but the biological mechanisms underlying hemorrhagic markers remain unclear. We assessed hemorrhage patterns in CAA to determine their associations with amyloid burden and related imaging markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Sixty\u2010two patients with probable CAA underwent Pittsburgh compound B\u2010positron emission tomography and structural magnetic resonance imaging. Participants were classified by dominant hemorrhagic pattern: lobar cerebral microbleed\u2010dominant (n=31), cortical superficial siderosis\u2010dominant (n=17), and nondominant (n=14). Global cortical amyloid burden was quantified as Pittsburgh compound B distribution volume ratio. White matter hyperintensity volume and high\u2010degree centrum semiovale\u2010enlarged perivascular spaces were assessed. Associations were tested using age\u2010 and sex\u2010adjusted regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Global Pittsburgh compound B distribution volume ratio was significantly higher in the cerebral microbleed\u2010dominant (1.40\u00b10.23) and cortical superficial siderosis\u2010dominant (1.45\u00b10.27) groups than nondominant group (1.20\u00b10.17;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.007 and\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.006, respectively), and these associations remained independent after adjustment (odds ratio [OR], 1.8 [95% CI, 1.1\u20132.8];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.009 and OR, 1.6 [95% CI, 1.1\u20132.5];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.020). Compared with the nondominant group, high\u2010degree centrum semiovale\u2010enlarged perivascular spaces were independently associated with both cerebral microbleed\u2010dominant (OR, 9.3 [95% CI, 1.6\u201352];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.011) and cortical superficial siderosis\u2010dominant (OR, 10 [95% CI, 1.6\u201362];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.013). In the full cohort, Pittsburgh compound B distribution volume ratio was independently associated with high\u2010degree centrum semiovale\u2010enlarged perivascular spaces (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.016) and white matter hyperintensity volume (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.049). Findings were unchanged in sensitivity analyses, adjusting for intracerebral hemorrhage.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Amyloid burden in CAA is associated with hemorrhage\u2010dominant patterns, high\u2010degree centrum semiovale\u2010enlarged perivascular spaces, and greater WMH volume. These findings support a close link between vascular amyloid deposition and downstream vascular brain injury, underscoring its relevance as a therapeutic target in CAA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.048858","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T09:11:58Z","timestamp":1778058718000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Hemorrhage Pattern and Amyloid Burden in Cerebral Amyloid Angiopathy"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2264-1603","authenticated-orcid":false,"given":"Elif","family":"Gokcal","sequence":"first","affiliation":[{"name":"J. Philip Kistler Hemorrhagic Stroke Research Program, Massachusetts General Hospital, Harvard Medical School","place":["Boston, USA"]},{"name":"Massachusetts General Hospital, Harvard Medical School","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7435-1338","authenticated-orcid":false,"given":"J. Alex","family":"Becker","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Harvard Medical School","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell J.","family":"Horn","sequence":"additional","affiliation":[{"name":"J. Philip Kistler Hemorrhagic Stroke Research Program, Massachusetts General Hospital, Harvard Medical School","place":["Boston, USA"]},{"name":"Massachusetts General Hospital, Harvard Medical School","place":["Boston, USA"]},{"name":"Yale University","place":["New Haven, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ofer","family":"Rotschild","sequence":"additional","affiliation":[{"name":"J. Philip Kistler Hemorrhagic Stroke Research Program, Massachusetts General Hospital, Harvard Medical School","place":["Boston, USA"]},{"name":"Massachusetts General Hospital, Harvard Medical School","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2313-977X","authenticated-orcid":false,"given":"Alvin S.","family":"Das","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Harvard Medical School","place":["Boston, USA"]},{"name":"Beth Israel Deaconess Medical Center, Harvard Medical School","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avia Abramovitz","family":"Fouks","sequence":"additional","affiliation":[{"name":"J. Philip Kistler Hemorrhagic Stroke Research Program, Massachusetts General Hospital, Harvard Medical School","place":["Boston, USA"]},{"name":"Massachusetts General Hospital, Harvard Medical School","place":["Boston, USA"]},{"name":"Austin Health","place":["Heidelberg, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1014-9138","authenticated-orcid":false,"given":"Jonathan","family":"Rosand","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Harvard Medical School","place":["Boston, USA"]},{"name":"McCance Center for Brain Health, Massachusetts General Hospital, Harvard Medical School","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5398-1816","authenticated-orcid":false,"given":"Anand","family":"Viswanathan","sequence":"additional","affiliation":[{"name":"J. Philip Kistler Hemorrhagic Stroke Research Program, Massachusetts General Hospital, Harvard Medical School","place":["Boston, USA"]},{"name":"Massachusetts General Hospital, Harvard Medical School","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith A.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital, Harvard Medical School","place":["Boston, USA"]},{"name":"Massachusetts General Hospital, Harvard Medical School","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2169-4457","authenticated-orcid":false,"given":"M. Edip","family":"Gurol","sequence":"additional","affiliation":[{"name":"J. Philip Kistler Hemorrhagic Stroke Research Program, Massachusetts General Hospital, Harvard Medical School","place":["Boston, USA"]},{"name":"Massachusetts General Hospital, Harvard Medical School","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1792-8887","authenticated-orcid":false,"given":"Steven M.","family":"Greenberg","sequence":"additional","affiliation":[{"name":"J. 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