{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:32:04Z","timestamp":1793320324218,"version":"4.5.0"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,7,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Sarcopenia is prevalent in patients with Fontan circulation and may contribute to functional decline and adverse outcomes. It is commonly assessed using the cross\u2010sectional area of the psoas muscle (PMA), although volumetric assessment of psoas muscle volume (PMV) may better capture true muscle mass. The ability of PMA versus PMV to differentiate patients with Fontan circulation from healthy controls and to provide incremental prognostic information remains incompletely defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">In this prospective study, abdominopelvic magnetic resonance imaging was used to quantify PMA and PMV in 70 patients with Fontan circulation and 51 healthy controls with similar age and sex distribution. PMA at the fourth lumbar level and total PMV were indexed to body surface area. Group differences were assessed using nonparametric testing. Prognostic associations were evaluated using multivariable logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Male patients with Fontan circulation had lower PMV and PMA indexed to body surface area than healthy male patients (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.029 and\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.008, respectively), while no significant differences were observed among female patients (PMV indexed to body surface area,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.073; PMA indexed to body surface area,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.135). In multivariable analysis, Fontan\u2010associated liver disease, lower serum total protein, and oxygen saturation were independently associated with Fontan failure. PMV indexed to body surface area demonstrated a modest inverse association with Fontan failure and modestly improved model discrimination when added to the clinical base model (cross\u2010validated area under the receiver operating characteristic curve, 0.84 versus 0.81), whereas PMA indexed to body surface area did not improve predictive performance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">PMV indexed to body surface area may provide incremental prognostic information and serve as an adjunctive imaging biomarker of sarcopenia in Fontan circulation, although its independent predictive value for adverse outcomes requires further validation in larger cohorts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.048924","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T10:36:28Z","timestamp":1782210988000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Magnetic Resonance Imaging\u2013Based Psoas Muscle Volume as an Additional Risk Factor for Fontan Failure: A Prospective Cohort Study"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5861-1026","authenticated-orcid":false,"given":"Sukran","family":"Erdem","sequence":"first","affiliation":[{"name":"Children's Health\u2013University of Texas Southwestern Medical Center","place":["Dallas, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4091-992X","authenticated-orcid":false,"given":"Tarique","family":"Hussain","sequence":"additional","affiliation":[{"name":"Children's Health\u2013University of Texas Southwestern Medical Center","place":["Dallas, USA"]},{"name":"The University of Texas Southwestern Medical Center","place":["Dallas, USA"]},{"name":"The University of Texas Southwestern Medical Center","place":["Dallas, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0173-2364","authenticated-orcid":false,"given":"Orhan","family":"Erdem","sequence":"additional","affiliation":[{"name":"University of North Texas","place":["Denton, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Qasim","family":"Mehdi","sequence":"additional","affiliation":[{"name":"Children's Health\u2013University of Texas Southwestern Medical Center","place":["Dallas, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7130-7056","authenticated-orcid":false,"given":"Ryan","family":"Butts","sequence":"additional","affiliation":[{"name":"Children's Health\u2013University of Texas Southwestern Medical Center","place":["Dallas, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7288-6566","authenticated-orcid":false,"given":"Franz Gerald","family":"Greil","sequence":"additional","affiliation":[{"name":"Children's Health\u2013University of Texas Southwestern Medical Center","place":["Dallas, USA"]},{"name":"The University of Texas Southwestern Medical Center","place":["Dallas, USA"]},{"name":"The University of Texas Southwestern Medical Center","place":["Dallas, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3777-4822","authenticated-orcid":false,"given":"Tarek","family":"Alsaied","sequence":"additional","affiliation":[{"name":"Children's Health\u2013University of Texas Southwestern Medical Center","place":["Dallas, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2729-2491","authenticated-orcid":false,"given":"Qing","family":"Zou","sequence":"additional","affiliation":[{"name":"Children's Health\u2013University of Texas Southwestern Medical Center","place":["Dallas, USA"]},{"name":"The University of Texas Southwestern Medical Center","place":["Dallas, USA"]},{"name":"The University of Texas Southwestern Medical Center","place":["Dallas, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afq034"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.13221"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00068-021-01669-1"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-014-2785-7"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00068-013-0313-3"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/jpm11121338"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-022-04234-4"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13071245"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000696"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-023-05100-2"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2021.799125"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivae188"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-024-03567-w"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951122001433"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951121001748"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2019.01.003"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2014-305723"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.015639"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjco.2019.12.004"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13293-019-0257-3"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2023.10.010"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2020.06.009"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.08.970"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2012-303347"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.06.008"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951120000864"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2019.07.625"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezs714"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2015.09.036"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezab298"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951124025708"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.125.048924","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T04:38:22Z","timestamp":1787719102000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.125.048924"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,7]]},"references-count":31,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2026,7,7]]}},"alternative-id":["10.1161\/JAHA.125.048924"],"URL":"https:\/\/doi.org\/10.1161\/jaha.125.048924","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,7]]},"assertion":[{"value":"2025-12-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e048924"}}