{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T07:56:37Z","timestamp":1790236597511,"version":"4.1.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,6,16]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Transthyretin amyloid cardiomyopathy (ATTR\u2010CM) is a rare, life\u2010threatening form of restrictive cardiomyopathy. Access to cardiology providers and specialized amyloid centers may impact ATTR\u2010CM diagnosis. We sought to elucidate diagnostic disparities of ATTR\u2010CM through assessment of diagnostic trends and the geographic distribution of amyloid centers and cardiology providers in the United States.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">This was a cross\u2010sectional geospatial analysis of amyloid centers and cardiology providers and a retrospective cohort analysis of patients with ATTR\u2010CM from the Komodo Healthcare Map from July 1, 2016, to June 30, 2024.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">Among 14\u2009980 patients, mean age was 74.8\u2009years, 62.3% were men, 54.1% were White individuals, and 28.8% were Black individuals. The diagnosed prevalence of ATTR\u2010CM was 35.68 per 100\u2009000 persons. Prevalence was highest in Black patients (102.17) and in the Northeast (52.63), and it increased 4\u2010fold over the study period. Mean distance of patients to a cardiology provider was 4.3 miles and to an amyloid center was 48.5 miles. Large areas of the country, particularly in the Midwest, were identified with limited cardiology providers and amyloid centers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">The prevalence of ATTR\u2010CM has increased substantially since 2017, with notable racial differences; however, there remain geographic disparities. Strategies to address these regional disparities need to be identified.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.048943","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T11:54:47Z","timestamp":1781006087000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Diagnostic Trends and Geographic Health Care Disparities Among Patients With Transthyretin Amyloid Cardiomyopathy"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7371-5742","authenticated-orcid":false,"given":"Joshua D.","family":"Mitchell","sequence":"first","affiliation":[{"name":"Washington University School of Medicine","place":["St. Louis, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4024-3691","authenticated-orcid":false,"given":"Kevin M.","family":"Alexander","sequence":"additional","affiliation":[{"name":"Stanford University School of Medicine","place":["Stanford, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9080-7243","authenticated-orcid":false,"given":"Hanh Dung","family":"Dao","sequence":"additional","affiliation":[{"name":"Genesis Research Group","place":["Hoboken, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Nagelhout","sequence":"additional","affiliation":[{"name":"Genesis Research Group","place":["Hoboken, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Lamarre","sequence":"additional","affiliation":[{"name":"Genesis Research Group","place":["Hoboken, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9019-3747","authenticated-orcid":false,"given":"Margarita","family":"Udall","sequence":"additional","affiliation":[{"name":"BridgeBio Pharma, Inc.","place":["San Francisco, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard K.","family":"Cheng","sequence":"additional","affiliation":[{"name":"University of Washington","place":["Seattle, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.04.003"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.5334\/gh.1262"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/13506129.2018.1498782"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.2217\/cer-2022-0074"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.118.038169"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/14737167.2021.1933948"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaccao.2024.05.001"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2024.04.054"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.118.005407"},{"key":"e_1_3_2_11_2","unstructured":"U.S. Census Bureau . 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