{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:08:41Z","timestamp":1789013321117,"version":"build-2803163510"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,8,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Coronary artery bypass grafting is the most commonly performed major surgical procedure worldwide. The prognostic value of preoperative functional status measures, including self\u2010perceived health, the physical domain of the MacNew heart\u2010related quality of life score, and estimated maximum oxygen consumption for long\u2010term mortality remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We included 1146 patients undergoing coronary artery bypass grafting across 7 hospitals in Israel. Three functional status indicators were assessed: self\u2010perceived health, MacNew physical domain score, and estimated maximum oxygen consumption. Associations with all\u2010cause mortality were examined using multivariable Cox regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Participants had a mean age of 65.6\u2009\u00b1\u200910\u2009years, and 260 (23%) were female. Over a median follow\u2010up of 15.4\u2009years (interquartile range, 10), 687 (59.6%) patients died. Multivariable Cox regression identified all functional status indicators to associate with mortality. Impaired self\u2010perceived health was the strongest predictor of mortality (hazard ratio [HR], 1.43 [95% CI, 1.2\u20131.7],\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001), followed by low baseline maximum oxygen consumption (HR, 1.2 [95% CI, 1.0\u20131.5],\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.05) and poor MacNew physical domain score (HR, 1.2 [95% CI, 1.0\u20131.4],\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.02). Discrimination, according to Harrell's C statistic was highest for self\u2010perceived health (C\u2010index, 0.729 [95% CI, 0.7\u20130.8],\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001). Net reclassification improvement analysis confirmed that self\u2010perceived health provided the greatest incremental value, correctly reclassifying 30% of participants (95% CI, 0.2\u20130.5;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001) for mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Self\u2010perceived health demonstrated better prognostic value, exceeding the functional status measures examined. Self\u2010perceived health, a single question indicator, should be considered a key measure for risk stratification and prognosis following coronary artery bypass grafting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Registration<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\">https:\/\/clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique identifier: NCT00356863.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.048997","type":"journal-article","created":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T10:16:41Z","timestamp":1784974601000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Functional Status Indicators and Long\u2010Term Mortality Following Elective Coronary Artery Bypass Grafting: A Multicenter Cohort Study"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6282-7167","authenticated-orcid":false,"given":"Yonatan","family":"Moshkovits","sequence":"first","affiliation":[{"name":"Rabin Medical Center","place":["Petah Tikva, Israel"]},{"name":"Tel Aviv University","place":["Tel Aviv, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6454-6000","authenticated-orcid":false,"given":"Rachel","family":"Dankner","sequence":"additional","affiliation":[{"name":"Sheba Medical Center","place":["Ramat Gan, Israel"]},{"name":"Tel Aviv University","place":["Tel Aviv, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1147-8686","authenticated-orcid":false,"given":"Arnona","family":"Ziv","sequence":"additional","affiliation":[{"name":"Sheba Medical Center","place":["Ramat Gan, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9123-8094","authenticated-orcid":false,"given":"Alon","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Tel Aviv University","place":["Tel Aviv, Israel"]},{"name":"Sheba Medical Center","place":["Ramat\u2010Gan, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","unstructured":"Cardiovascular diseases (CVDs). World Health Organization. https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/cardiovascular\u2010diseases\u2010(cvds)."},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2018.02.43"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.022572"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1608042"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.11.053"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0804626"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezac043"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.640573"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000002806"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezt358"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1010-7940(00)00542-x"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13019-020-01273-1"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2014.02.009"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1010-7940(03)00413-5"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0147-9563(00)90035-9"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0003-4975(03)00019-5"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/80.8.782"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/clc.23579"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-021-02884-4"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199206000-00002"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-2-3"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.006096"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-20414-1"},{"key":"e_1_3_2_25_2","first-page":"566","article-title":"Development of a Hebrew questionnaire to be used in epidemiological studies to assess physical fitness\u2014validation against sub maximal stress test and predicted VO2 max","volume":"143","author":"Ken\u2010Dror G","year":"2004","unstructured":"Ken\u2010Dror G, Lerman Y, Segev S, Dankner R. Development of a Hebrew questionnaire to be used in epidemiological studies to assess physical fitness\u2014validation against sub maximal stress test and predicted VO2 max. Harefuah. 2004;143:566\u201372, 623.","journal-title":"Harefuah"},{"key":"e_1_3_2_26_2","first-page":"760","article-title":"Health\u2010related quality of life of Israeli heart patients according to the MacNew heart disease specific instrument","volume":"150","author":"Dankner R","year":"2011","unstructured":"Dankner R, Burya\u2010Sa'adon L, Geulayov G, Kobalyov A, Drory Y. Health\u2010related quality of life of Israeli heart patients according to the MacNew heart disease specific instrument. 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