{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T07:03:36Z","timestamp":1789715016537,"version":"4.0.1"},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,5,19]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Inconsistent links between arterial stiffness and cognition may reflect limited cognitive tests and unaccounted diurnal pulse wave velocity variation. To bridge this knowledge gap, we investigated 24\u2010hour ambulatory estimated pulse wave velocity (ePWV) and its association with dementia\u2010related neuroimaging and cognitive function in hypertension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We assessed 893 patients with hypertension aged \u226550\u2009years (mean age, 67.2\u2009years; 52.3% women), including brain magnetic resonance imaging (n=545), global cognitive testing (n=623), and ambulatory ePWV measurements. White matter hyperintensity and hippocampus were quantified via Computational Anatomy Toolbox\u00a012 and Statistical Parametric Maps 12. Cognition was assessed via the Mini\u2010Mental State Examination and Montreal Cognitive Assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Among 623 tested participants, the prevalence of mild cognitive impairment was 10% (Mini\u2010Mental State Examination, n=62) and 18.5% (Montreal Cognitive Assessment, n=115). Cognitive scores decline with higher white matter hyperintensity burden and lower hippocampal volume (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      \u22640.024). Higher 24\u2010hour ePWV quartiles showed graded associations with higher white matter hyperintensity volume and lower hippocampal volume (both\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001) and lower cognitive scores (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      \u22640.037). Multivariable models showed each 1\u2010SD (+1.2\u2009m\/s) increment in 24\u2010hour ePWV were associated with 2.00\u00b11.74\u2009mL greater white matter hyperintensity volume (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.004), and 0.54\u00b10.14\u2009mL smaller hippocampal volume (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001), independent of age, systolic blood pressure, and other confounders. These associations persisted after further adjustment for carotid\u2013femoral PWV, which itself showed no independent association (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      \u22650.18). Results were consistent for daytime and nighttime ePWV and across key subgroups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Ambulatory ePWV is an independent risk factor for dementia\u2010related brain pathology. Targeting arterial stiffness represents a promising strategy for dementia prevention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.049028","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T09:13:36Z","timestamp":1778058816000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Associations of Brain Morphology and Cognitive Function With Ambulatory Estimated Pulse Wave Velocity"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3822-3504","authenticated-orcid":false,"given":"Yi\u2010Bang","family":"Cheng","sequence":"first","affiliation":[{"name":"Shanghai Jiaotong University School of Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian\u2010Hui","family":"Guo","sequence":"additional","affiliation":[{"name":"Shanghai Jiaotong University School of Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7500-7114","authenticated-orcid":false,"given":"Yi","family":"Chen","sequence":"additional","affiliation":[{"name":"Shanghai Jiaotong University School of Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai Jiaotong University School of Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9121-5872","authenticated-orcid":false,"given":"Yuan\u2010Yuan","family":"Kang","sequence":"additional","affiliation":[{"name":"Shanghai Jiaotong University School of Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5637-4708","authenticated-orcid":false,"given":"Ting\u2010Yan","family":"Xu","sequence":"additional","affiliation":[{"name":"Shanghai Jiaotong University School of Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5825-5968","authenticated-orcid":false,"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Shanghai Jiaotong University School of Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010Guang","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Jiaotong University School of Medicine","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","unstructured":"World Health Organization (WHO) . 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