{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T14:31:24Z","timestamp":1793802684534,"version":"4.6.1"},"reference-count":66,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,7,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Carotid intima\u2010media thickness (cIMT) is a noninvasive marker of subclinical atherosclerosis linked to future cardiovascular disease (CVD). However, its relationship with early cardiac remodeling and shared genetic basis with cardiovascular disease remain poorly understood. We investigated the phenotypic and genetic associations between cIMT, aortic and cardiac traits, and cardiovascular disease in the UK Biobank, a large population\u2010based cohort with comprehensive imaging and genetics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We analyzed 46\u2009102 participants with carotid ultrasound and cardiac magnetic resonance imaging, excluding those with prevalent heart failure, atrial fibrillation, or stroke. Multivariable linear and Cox regression models assessed associations between common cIMT, aortic and cardiac traits, and incident cardiovascular disease, with effect estimates expressed per 1 SD increase in cIMT. Genetic correlations and pathway enrichment analyses were performed using genome\u2010wide association studies summary statistics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Higher cIMT was associated with aortic enlargement, left ventricular hypertrophy, and greater chamber volumes, alongside reduced biatrial ejection fractions (all\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001). Higher left cIMT was associated with lower dilated cardiomyopathy (hazard ratio [HR], 0.475 [95% CI, 0.23\u20130.98],\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.04\n                      <jats:italic toggle=\"no\">)<\/jats:italic>\n                      risk. Genetically, cIMT correlated positively with aortic and ventricular traits and negatively with left atrial ejection fraction. Seven shared genes (\n                      <jats:italic toggle=\"no\">CDH13, HAND2, ITCH, FBXO32, TBX20, FBN1<\/jats:italic>\n                      , and\n                      <jats:italic toggle=\"no\">CBFA2AT3)<\/jats:italic>\n                      were enriched in pathways related to extracellular matrix organization, vascular development, and cardiac morphogenesis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p xml:lang=\"en\">Increased cIMT is associated with systemic aortic and cardiac remodeling and decreased dilated cardiomyopathy risk. Integrative genetic analyses revealed shared heritable mechanisms, highlighting cIMT as a marker of early cardiovascular structural change, potentially bridging vascular and cardiac disease processes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.049139","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T10:20:43Z","timestamp":1783074043000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Integrative Observational and Genetic Evidence From the UK Biobank Supports Carotid Intima\u2010Media Thickness as a Window Into Cardiac Remodeling"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6294-3956","authenticated-orcid":false,"given":"Si Hui","family":"Chong","sequence":"first","affiliation":[{"name":"University College London","place":["London, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adama 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