{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T06:17:33Z","timestamp":1788329853880,"version":"build-2803163510"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Sex differences in clinical presentations of heart failure (HF) are pervasive, yet differences in invasive hemodynamic measures across HF subtypes remain incompletely characterized. Understanding these distinctions is critical, as sex\u2010specific physiology influences disease progression and prognostic assessment in HF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We conducted a retrospective cohort study of 1818 patients with HF who underwent clinically indicated right heart catheterization, stratified by preserved versus reduced ejection fraction. We examined the association of sex with invasive hemodynamic measures of right ventricular, pulmonary vascular, and left ventricular function using multivariable linear regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      We studied n=709 individuals with heart failure with preserved ejection fraction (HFpEF) (44% women, mean age 68\u00b110\u2009years) and n=1109 with heart failure with reduced ejection fraction (HFrEF) (26% women, mean age 64\u00b112\u2009years). Women and men had similar measures of right ventricular function across HF subtypes (multivariable\u2010adjusted\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &gt;0.05 for all). However, women with both HFpEF and HFrEF exhibited worse pulmonary vascular function, with significantly higher pulmonary vascular resistance and lower pulmonary artery compliance (multivariable\u2010adjusted\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001). Women with both HFpEF and HFrEF had similar cardiac power index, but higher aortic pulsatility index (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.01 for HFpEF;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001 for HFrEF).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Among a large hospital\u2010based sample of patients with HF, women and men exhibited similar indices of right ventricular function, despite women having worse pulmonary vascular function. Cardiac power index was similar between sexes in both HFpEF and HFrEF, whereas aortic pulsatility index was higher in women with HFrEF. Taken together, sex differences in hemodynamic measures were largely similar across individuals with HFpEF and HFrEF. Future studies are needed to delineate clinical implications of these sex differences.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.050009","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T11:25:26Z","timestamp":1787225126000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Sex Differences in Right Ventricular, Pulmonary Vascular, and Integrated Hemodynamic Measures of Cardiac Function in HFpEF and HFrEF"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4286-881X","authenticated-orcid":false,"given":"Meihan","family":"Guo","sequence":"first","affiliation":[{"name":"Beth Israel Deaconess Medical Center","place":["Boston, USA"]},{"name":"Harvard Medical School","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6510-0073","authenticated-orcid":false,"given":"Juhi K.","family":"Parekh","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9361-6397","authenticated-orcid":false,"given":"Emily S.","family":"Lau","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital","place":["Boston, USA"]},{"name":"Harvard Medical School","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2482-0444","authenticated-orcid":false,"given":"Leah B.","family":"Kosyakovsky","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center","place":["Boston, USA"]},{"name":"Harvard Medical School","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5244-0647","authenticated-orcid":false,"given":"Louisa A.","family":"Mounsey","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center","place":["Boston, USA"]},{"name":"Harvard Medical School","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Pomerantsev","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital","place":["Boston, USA"]},{"name":"Harvard Medical School","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9264-3243","authenticated-orcid":false,"given":"Michael H.","family":"Picard","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital","place":["Boston, USA"]},{"name":"Harvard Medical School","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7987-4768","authenticated-orcid":false,"given":"Jennifer E.","family":"Ho","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center","place":["Boston, USA"]},{"name":"Harvard Medical School","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2019.01.004"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2021.10.019"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.03.060"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.13246"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-022-00376-4"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000477"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000001940"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198710223171717"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.119.006591"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/circheartfailure.120.007081"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2021.05.010"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.121.009085"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2084"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacadv.2023.100327"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-19507-7"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.23309"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2025.09.046"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.623129"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/pul2.12288"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.110.958801"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2018.10.009"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.831179"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.268"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/function\/zqab066"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.541078"}],"container-title":["Journal 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