{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:53:00Z","timestamp":1791355980222,"version":"4.3.1"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"19","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,10,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Improving health status is a fundamental goal after myocardial infarction (MI). Whether health status differs between type 1 and type 2 MI is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">In this prospective study, 150 patients hospitalized with type 1 (n=75) and type 2 MI (n=75) were enrolled. Health status was assessed at baseline, 1, and 4\u2009months using the EuroQol 5\u2010Dimension 5\u2010Level visual analogue scale, 7\u2010item Seattle Angina Questionnaire, Patient\u2010Reported Outcomes Measurement Information System Physical Function, Patient\u2010Reported Outcomes Measurement Information System Fatigue, FRAIL Scale, and Patient Health Questionnaire\u20109.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      A total of 149 baseline, 92 one\u2010month, and 92 four\u2010month assessments were analyzed. Patients with type 2 MI were older, were more frequently women, and had more comorbidities. Baseline health status was similar between type 2 and type 1 MI (EuroQol 5\u2010Dimension 5\u2010Level visual analog scale, 66.20\u00b122.17 versus 69.36\u00b120.67;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.37). At 1 and 4 months, the EuroQol 5\u2010Dimension 5\u2010Level visual analog scale was lower for type 2 MI, and adjusted analyses demonstrated less improvement (difference, \u2212\u20094.8 points;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.04). Patients with type 2 MI had lower physical function and greater frailty throughout follow\u2010up. Baseline fatigue and depression were similar but modestly worse for type 2 MI at follow\u2010up. Baseline 7\u2010item Seattle Angina Questionnaire scores were higher for type 2 MI but were similar between groups at follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Although baseline overall health status was similar, patients with type 2 MI experienced smaller improvements in health status and reported a greater burden of frailty and impaired physical function over 4 months. These findings highlight the need to address health status domains beyond angina after type 2 MI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.050146","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:43:14Z","timestamp":1790311394000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of Health Status Among Patients With Type 1 Myocardial Infarction and Type 2 Myocardial Infarction: The CHAMP\u2010MI Study"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5928-5974","authenticated-orcid":false,"given":"Se\u00e1n P.","family":"Murphy","sequence":"first","affiliation":[{"name":"Heart and Vascular Institute, Mass General Brigham","place":["Boston, USA"]},{"name":"Harvard Medical School","place":["Boston, 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Institute, Mass General Brigham","place":["Boston, USA"]},{"name":"Harvard Medical School","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5524-4721","authenticated-orcid":false,"given":"Gheorghe","family":"Doros","sequence":"additional","affiliation":[{"name":"Boston University School of Public Health","place":["Boston, USA"]},{"name":"Baim Institute for Clinical Research","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5274-0826","authenticated-orcid":false,"given":"Dalane W.","family":"Kitzman","sequence":"additional","affiliation":[{"name":"Wake Forest University School of Medicine","place":["Winston\u2010Salem, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8402-7435","authenticated-orcid":false,"given":"Pradeep","family":"Natarajan","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute, Mass General Brigham","place":["Boston, USA"]},{"name":"Harvard Medical School","place":["Boston, USA"]},{"name":"Broad Institute of Harvard and MIT","place":["Cambridge, USA"]},{"name":"Massachusetts General Hospital","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8338-1798","authenticated-orcid":false,"given":"James L.","family":"Januzzi","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute, Mass General Brigham","place":["Boston, USA"]},{"name":"Harvard Medical School","place":["Boston, USA"]},{"name":"Baim Institute for Clinical Research","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2839-2611","authenticated-orcid":false,"given":"John A.","family":"Spertus","sequence":"additional","affiliation":[{"name":"University of Missouri\u2010Kansas City's Healthcare Institute for Innovations in Quality and Saint Luke's Mid America Heart Institute","place":["Kansas City, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5013-6112","authenticated-orcid":false,"given":"Cian P.","family":"McCarthy","sequence":"additional","affiliation":[{"name":"Heart and Vascular Institute, Mass General Brigham","place":["Boston, USA"]},{"name":"Harvard Medical School","place":["Boston, USA"]},{"name":"Baim Institute for Clinical Research","place":["Boston, 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