{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:52:58Z","timestamp":1791355978169,"version":"4.3.1"},"reference-count":59,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"19","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,10,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Recent clinical trials have shown that colchicine, an anti\u2010inflammatory agent, is superior in preventing postoperative atrial fibrillation (POAF) in patients after open heart surgery. However, the systemic use of colchicine was associated with an increased incidence of gastrointestinal adverse effects, often leading patients to discontinue treatment. The objective of this study was to evaluate the effectiveness and safety of biatrial epicardial colchicine\u2010eluting bioresorbable polymer mesh for preventing POAF in a swine sterile pericarditis model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Twelve domestic pigs underwent initial pericarditis surgery. During the creation of the swine sterile pericarditis model, either colchicine\u2010eluting bioresorbable mesh (0.5\u20131 mg\/day, 6 pigs) or only bioresorbable mesh without the drug (6 pigs) was placed on both atria. On postoperative days 1 and 2, we measured the electrophysiological properties, including pacing threshold, atrial effective refractory period, and inducibility of POAF. Blood and tissue samples were obtained to assess systemic and local inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      The pacing threshold was significantly lower and the atrial effective refractory period was significantly longer in the colchicine\u2010treated pericarditis pigs compared with the pericarditis control pigs. The inducibility of POAF episodes was significantly lower in the colchicine\u2010treated pericarditis pigs (median of POAF episodes: 0,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.05; 3\/6 pigs) compared with the pericarditis control pigs (median of POAF episodes: 1.5; 6\/6 pigs). RNA sequencing analysis of local tissue revealed a decrease in differentially expressed genes associated with inflammation and cardiotoxicity in the colchicine\u2010treated group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Biatrial epicardial colchicine\u2010eluting bioresorbable polymer mesh significantly diminished atrial inflammation, thereby reducing the inducibility of POAF in a swine sterile pericarditis model.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.050242","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T13:26:08Z","timestamp":1789737968000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Novel Biatrial Epicardial Colchicine\u2010Eluting Bioresorbable Polymer Mesh for the Prevention of Postoperative Atrial Fibrillation: A Proof\u2010of\u2010Concept Study"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0122-1134","authenticated-orcid":false,"given":"Seungyup","family":"Lee","sequence":"first","affiliation":[{"name":"Case Western Reserve University","place":["Cleveland, USA"]},{"name":"Case Western Reserve University","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragan","family":"Juzbasich","sequence":"additional","affiliation":[{"name":"Case Western Reserve University","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4082-5230","authenticated-orcid":false,"given":"Yu","family":"Cui","sequence":"additional","affiliation":[{"name":"Northeastern University","place":["Boston, USA"]},{"name":"University of Akron","place":["Akron, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deliris","family":"Ortiz","sequence":"additional","affiliation":[{"name":"University of Akron","place":["Akron, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celeen","family":"Khrestian","sequence":"additional","affiliation":[{"name":"Case Western Reserve University","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Don W.","family":"Wallick","sequence":"additional","affiliation":[{"name":"Case Western Reserve University","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Laurita","sequence":"additional","affiliation":[{"name":"Case Western Reserve University","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3861-8862","authenticated-orcid":false,"given":"Oleksandra","family":"Pavlova","sequence":"additional","affiliation":[{"name":"Case Western Reserve University","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8830-1809","authenticated-orcid":false,"given":"Andrei","family":"Maiseyeu","sequence":"additional","affiliation":[{"name":"Case Western Reserve University","place":["Cleveland, USA"]},{"name":"Case Western Reserve University","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aarushi","family":"Nayak","sequence":"additional","affiliation":[{"name":"Case Western Reserve University","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Chacon","sequence":"additional","affiliation":[{"name":"Case Western Reserve University","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias","family":"Veizi","sequence":"additional","affiliation":[{"name":"Case Western Reserve University","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1419-604X","authenticated-orcid":false,"given":"Jayakumar","family":"Sahadevan","sequence":"additional","affiliation":[{"name":"Case Western Reserve University","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7781-3817","authenticated-orcid":false,"given":"Abraham","family":"Joy","sequence":"additional","affiliation":[{"name":"Northeastern University","place":["Boston, USA"]},{"name":"University of Akron","place":["Akron, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(93)90894-N"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199710000-00011"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.046940"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.023921"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2015.06.015"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2024.08.014"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2019.07.008"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40140-019-00321-4"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-019-0166-5"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2010.03.011"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2021.10.002"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-021-02654-7"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.2459\/JCM.0000000000001079"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euad169"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.11026"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.067097"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.120.008503"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1901111"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/bm400697u"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.5b02399"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.8b00964"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.9b00383"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1039\/c8py00492g"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.5b00585"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsmacrolett.8b00118"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.macromol.8b01781"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.9b00939"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/admi.201700506"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.3c00684"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/ilar.43.4.244"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/pace.14765"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2005.11.028"},{"key":"e_1_3_1_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2007.00970.x"},{"key":"e_1_3_1_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/pace.15220"},{"key":"e_1_3_1_36_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.030907"},{"key":"e_1_3_1_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl272"},{"key":"e_1_3_1_38_2","doi-asserted-by":"publisher","DOI":"10.1177\/145749691210100413"},{"key":"e_1_3_1_39_2","doi-asserted-by":"publisher","DOI":"10.3923\/pjbs.2009.1325.1329"},{"key":"e_1_3_1_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)02490-9"},{"key":"e_1_3_1_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2022.11.007"},{"key":"e_1_3_1_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2025.05.045"},{"key":"e_1_3_1_43_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.115.003199"},{"key":"e_1_3_1_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2018.08.021"},{"key":"e_1_3_1_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.10.049"},{"key":"e_1_3_1_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2023.04.040"},{"key":"e_1_3_1_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2024.11.014"},{"key":"e_1_3_1_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2025.06.005"},{"key":"e_1_3_1_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)01689-6"},{"key":"e_1_3_1_50_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.1032116"},{"key":"e_1_3_1_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110384"},{"key":"e_1_3_1_52_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00607.2006"},{"key":"e_1_3_1_53_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002128"},{"key":"e_1_3_1_54_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.120.316710"},{"key":"e_1_3_1_55_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2020.00062"},{"key":"e_1_3_1_56_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euv019"},{"key":"e_1_3_1_57_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.475194"},{"key":"e_1_3_1_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2006.03.024"},{"key":"e_1_3_1_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2011.09.074"},{"key":"e_1_3_1_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2024.10.033"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.125.050242","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:24:29Z","timestamp":1791354269000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.125.050242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,6]]},"references-count":59,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2026,10,6]]}},"alternative-id":["10.1161\/JAHA.125.050242"],"URL":"https:\/\/doi.org\/10.1161\/jaha.125.050242","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,6]]},"assertion":[{"value":"2026-03-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e050242"}}