{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T16:59:22Z","timestamp":1785257962999,"version":"3.55.0"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"14","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,7,21]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Vascular aging (VA) is a promising concept for cardiovascular risk assessment, but the optimal vascular indicator for vascular age calculation remains uncertain. This study aimed to compare VA indices on the basis of different vascular indicators for predicting cardiovascular events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">This prospective study included 3561 participants from a Chinese community\u2010based cohort. Four distinct VA indices including brachial\u2013ankle pulse wave velocity (baPWV), carotid intima\u2010media thickness, carotid plaque, or ankle\u2013brachial index, and conventional risk factors were calculated to predict age. \u0394Age was defined as the residual from a linear regression of vascular age on chronological age. Supernormal VA and early VA were defined by the 10th and 90th percentiles of \u0394Age, respectively. Cox proportional hazards models were used to investigate associations with major adverse cardiovascular events (MACEs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">During a mean 7.2\u2010year follow\u2010up, 294 participants experienced MACEs. After multivariable adjustment, only baPWV\u2010based \u0394Age was associated with MACE (hazard ratio [HR] per SD, 1.14 [95% CI, 1.02\u20131.27]). Early VA phenotype based on baPWV was associated with a higher risk of MACEs (HR, 1.44 [95% CI, 1.05\u20131.97]), whereas supernormal VA phenotype was not protective. VA indices based on carotid intima\u2010media thickness, carotid plaque, or ankle\u2013brachial index showed no significant associations with MACEs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">In this Chinese community\u2010based cohort, baPWV was the superior indicator for calculating VA indices, compared with carotid intima\u2010media thickness, carotid plaque, and ankle\u2013brachial index. baPWV\u2010based \u0394Age and early VA phenotype were independently associated with cardiovascular events, while other indicators were not. baPWV\u2010based VA demonstrates clinical utility for improving cardiovascular risk stratification.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.126.048948","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T10:54:50Z","timestamp":1784285690000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of Vascular Aging Models on the Basis of Different Vascular Indicators for Cardiovascular Events Prediction: A Chinese Community\u2010Based Cohort Study"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8830-1205","authenticated-orcid":false,"given":"Haotai","family":"Xie","sequence":"first","affiliation":[{"name":"Peking University First Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8351-4821","authenticated-orcid":false,"given":"Fangfang","family":"Fan","sequence":"additional","affiliation":[{"name":"Peking University First Hospital","place":["Beijing, China"]},{"name":"Peking University First Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Jia","sequence":"additional","affiliation":[{"name":"Peking University First Hospital","place":["Beijing, China"]},{"name":"Peking University First Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8526-1095","authenticated-orcid":false,"given":"Jianping","family":"Li","sequence":"additional","affiliation":[{"name":"Peking University First Hospital","place":["Beijing, China"]},{"name":"Peking University First Hospital","place":["Beijing, China"]},{"name":"Peking University","place":["Beijing, China"]},{"name":"Peking University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5407-8610","authenticated-orcid":false,"given":"Yanjun","family":"Gong","sequence":"additional","affiliation":[{"name":"Peking University First Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7508-4160","authenticated-orcid":false,"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Peking University First Hospital","place":["Beijing, China"]},{"name":"Peking University First Hospital","place":["Beijing, China"]},{"name":"Peking University","place":["Beijing, China"]},{"name":"Peking University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.11.010"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpc.2022.100432"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.11.062"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/2047487314566999"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurjpc\/zwad028"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/lifemedi\/lnad033"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-021-00678-2"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.03.352"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-023-04332-z"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.120.14971"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2023.1278795"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.119.12655"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.895792"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacasi.2023.07.014"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.115.07019"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/s2213-8587(21)00047-4"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1159\/000343145"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.116.022367"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.2471\/blt.15.153148"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.11.061"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvaf138"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.2147\/cia.S485597"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-025-02281-1"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.123.21314"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40119-022-00261-x"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1177\/00033197241226512"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1177\/2047487313518479"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.121.319902"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/brv.12866"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.14336\/ad.2024.0201-1"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1159\/000528208"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.126.048948","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T16:08:33Z","timestamp":1785254913000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.126.048948"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,21]]},"references-count":31,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2026,7,21]]}},"alternative-id":["10.1161\/JAHA.126.048948"],"URL":"https:\/\/doi.org\/10.1161\/jaha.126.048948","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,21]]},"assertion":[{"value":"2026-01-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e048948"}}