{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:36:01Z","timestamp":1787160961807,"version":"build-2736575974"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"16","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,8,18]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Hemolysis is a recognized complication of mechanical circulatory support and may contribute to acute kidney injury in patients with cardiogenic shock. Early hemolysis during Impella support, particularly compared with intra\u2010aortic balloon pump (IABP), remains incompletely characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We retrospectively analyzed a single\u2010center registry of consecutive patients with cardiogenic shock treated with IABP or Impella between August 2022 and October 2024. Serum haptoglobin was measured at intensive care unit admission and every 12 hours during device support. Low haptoglobin was defined as &lt;19 mg\/dL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Among 91 patients (IABP, n=67; Impella CP, n=24), baseline haptoglobin levels were similar. Patients supported with Impella exhibited a significantly greater decline in haptoglobin beginning 12 hours after intensive care unit admission, particularly in the absence of concomitant venoarterial extracorporeal membrane oxygenation. Low haptoglobin occurred more frequently with Impella than with IABP (67% versus 31%,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.004), whereas the incidence of overt clinical hemolysis was low and comparable between devices. Impella use (odds ratio, 2.82 [95% CI, 1.45\u20135.95];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.001), concomitant venoarterial extracorporeal membrane oxygenation support (odds ratio, 16.52 [95% CI, 4.65\u2013174.56];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001), and lower mean arterial pressure at intensive care unit admission (OR, 0.95 [95% CI, 0.89\u20130.99];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.006) were independently associated with low haptoglobin.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">In patients with cardiogenic shock, Impella CP support was associated with earlier and more frequent decline in serum haptoglobin compared with IABP, suggesting more frequent subclinical hemolysis. Although overt hemolysis was uncommon, early monitoring using serial serum haptoglobin measurements may help inform device management strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.126.049038","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T03:42:10Z","timestamp":1786160530000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Early Decline in Serum Haptoglobin During Impella CP Support Compared With Intra\u2010Aortic Balloon Pump in Cardiogenic Shock: A Single\u2010Center Observational Study"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1179-3718","authenticated-orcid":false,"given":"Shoji","family":"Kawakami","sequence":"first","affiliation":[{"name":"Aso Iizuka Hospital","place":["Fukuoka, Japan"]},{"name":"Kurume University Hospital","place":["Fukuoka, Japan"]},{"name":"Kurume University School of Medicine","place":["Fukuoka, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Aso Iizuka Hospital","place":["Fukuoka, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Takei","sequence":"additional","affiliation":[{"name":"Aso Iizuka Hospital","place":["Fukuoka, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4479-3956","authenticated-orcid":false,"given":"Yoshihiro","family":"Ota","sequence":"additional","affiliation":[{"name":"Aso Iizuka Hospital","place":["Fukuoka, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0785-1940","authenticated-orcid":false,"given":"Yosuke","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Aso Iizuka Hospital","place":["Fukuoka, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6216-3039","authenticated-orcid":false,"given":"Shihomi","family":"Nawata","sequence":"additional","affiliation":[{"name":"Aso Iizuka Hospital","place":["Fukuoka, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5647-9122","authenticated-orcid":false,"given":"Eigo","family":"Nawata","sequence":"additional","affiliation":[{"name":"Aso Iizuka Hospital","place":["Fukuoka, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6266-3393","authenticated-orcid":false,"given":"Hidenobu","family":"Koga","sequence":"additional","affiliation":[{"name":"Aso Iizuka Hospital","place":["Fukuoka, 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