{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T06:17:21Z","timestamp":1788329841059,"version":"build-2803163510"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Myeloperoxidase may promote plaque instability, while granulocyte colony\u2010stimulating factor may aggravate inflammation. We investigated their associations with intracranial artery plaque, stenosis, atherosclerotic burden, and plaque progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">This analysis included 3059 participants from the PRECISE (Polyvascular Evaluation for Cognitive Impairment and Vascular Events) study in China. Intracranial artery plaque, stenosis, and intracranial atherosclerotic burden were assessed using 3.0\u2010T magnetic resonance imaging at baseline (2017\u20132019) and 2 follow\u2010ups (2019\u20132022 and 2022\u20132024). Logistic regression and restricted cubic spline models were used to evaluate associations between biomarkers and intracranial atherosclerosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Participants had a median age of 61\u2009years, and 53.4% were women. Restricted cubic spline analyses indicated linear associations of higher myeloperoxidase and granulocyte colony\u2010stimulating factor levels with intracranial atherosclerosis. Each 1\u2010SD increase in myeloperoxidase was associated with intracranial artery plaque (odds ratio [OR], 1.12 [95% CI, 1.02\u20131.23]), stenosis (OR, 1.19 [95% CI, 1.02\u20131.39]), and higher intracranial atherosclerotic burden (common OR, 1.12 [95% CI, 1.02\u20131.23]) at baseline, as well as plaque progression at wave 2 (OR, 1.18 [95% CI, 1.07\u20131.30) and wave 3 (OR, 1.13 [95% CI, 1.02\u20131.26). Continuous granulocyte colony\u2010stimulating factor levels were not significantly associated with these outcomes; however, its highest tertile was associated with baseline intracranial artery plaque and higher intracranial atherosclerotic burden versus the lowest tertile (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      for trend&lt;0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Elevated myeloperoxidase and granulocyte colony\u2010stimulating factor levels were associated with intracranial atherosclerosis and plaque progression over \u22484.7\u2009years, highlighting the role of neutrophil\u2010driven inflammation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.126.049169","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T11:52:25Z","timestamp":1787226745000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Myeloperoxidase and Granulocyte Colony\u2010Stimulating Factor With Intracranial Atherosclerosis Presence and Progression From a Community\u2010Based Study"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3233-0028","authenticated-orcid":false,"given":"Ziqian","family":"Xu","sequence":"first","affiliation":[{"name":"Capital Medical University","place":["Beijing, China"]},{"name":"China National Clinical Research Center for Neurological Diseases","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Capital Medical 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