{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:38:20Z","timestamp":1792647500994,"version":"4.5.0"},"reference-count":67,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"20","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,10,20]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Omega\u20106 polyunsaturated fatty acids (PUFAs) have previously been associated with several peripheral artery disease (PAD) risk factors. We studied the association between individual omega\u20106 PUFAs and incident PAD in a multicohort analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">This study was conducted among participants from 9 cohorts (N=137\u2009704; PAD cases=2014) in the FORCE (Fatty Acids and Outcomes Research Consortium) who were free of clinical PAD at baseline. Omega\u20106 PUFAs were measured at baseline and with a median follow\u2010up of 14\u2009years. Cox proportional hazards regression analyses were conducted in individual cohorts to evaluate associations of omega\u20106 PUFAs (continuous cohort\u2010standardized interquintile ranges [difference between the medians of the 10th and 90th omega\u20106 PUFAs percentiles] and cohort\u2010specific quintiles) with incident clinical PAD adjusting for prespecified covariates. Inverse\u2010variance weighted meta\u2010analysis was used to calculate the combined hazard ratios (HRs) and 95% CIs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Linoleic acid (LA) was measured in all 9 cohorts, arachidonic acid in 8 (N=33\u2009541; PAD cases=1766), dihomo\u2010\u03b3\u2010LA and \u03b3\u2010LA in 7 (N=29\u2009861; PAD cases=1686), and eicosadienoic acid in 6 (N=27\u2009538; PAD cases=1435). Only LA was associated with a lower risk of incident PAD (quintile 5 versus quintile 1: HR, 0.75 [95% CI, 0.64\u20130.89];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.0009). Results did not differ in a statistically significant manner by age, sex, diabetes status, or smoking status.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Results suggest that the omega\u20106 PUFA LA may be protective against PAD, and other omega\u20106 PUFAs are not associated with PAD incidence. This is further evidence that omega\u20106 PUFA\u2014disease relationships should be evaluated by individual fatty acids rather than grouped as total omega\u20106 PUFAs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.126.049223","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T11:52:25Z","timestamp":1791633145000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Omega\u20106 Polyunsaturated Fatty Acids and Peripheral Artery Disease: An Individual Participant\u2010Level Analysis of 9 International Prospective Studies"],"prefix":"10.1161","volume":"15","author":[{"given":"Sarah O.","family":"Nomura","sequence":"first","affiliation":[{"name":"University of Minnesota","place":["Minneapolis, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6322-9118","authenticated-orcid":false,"given":"Natalie 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