{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:53:46Z","timestamp":1791356026606,"version":"4.3.1"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"19","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,10,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Retinal vascular occlusions (RVaO) are signs of systemic vascular disease and share risk factors with stroke and myocardial infarction. The cardiovascular risk of RVaO subtypes and their relationship to transient ischemic attack (TIA) remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Using the TriNetX database, we compared the 1\u2010year incidence of major adverse cardiovascular events (MACE), including ischemic and hemorrhagic stroke, acute myocardial infarction, and death, between patients with RVaO and those with TIA. Cox regression was used to analyze the association between risk factors and MACE risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">We identified 91\u2009936 patients with RVaO and 392\u2009069 patients with TIA. After propensity score matching, each cohort included 90\u2009698 patients. The RVaO cohort had a significantly lower 1\u2010year MACE risk than the TIA cohort (hazard ratio [HR], 0.77 [95% CI, 0.74\u20130.80]), with reduced risks of ischemic stroke (HR, 0.64 [95% CI, 0.60\u20130.67]), hemorrhagic stroke (HR, 0.82 [95% CI, 0.71\u20130.94]), and acute myocardial infarction (HR, 0.89 [95% CI, 0.83\u20130.96]). All\u2010cause mortality was similar. Subtype\u2010specific analysis showed that patients with central retinal artery occlusion had higher risks of MACE (HR, 1.13 [95% CI, 1.02\u20131.24]) and all\u2010cause mortality (HR, 1.23 [95% CI, 1.02\u20131.49]) than patients with TIA. Within RVaO, age, male sex, retinal artery occlusion, ischemic heart disease, chronic kidney disease, heart failure, and nicotine dependence were important predictors of MACE risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Patients with RVaO have a lower 1\u2010year MACE risk than TIA, but this varies by subtype. central retinal artery occlusion has a prognosis similar to TIA, requiring urgent assessment and prevention. These findings highlight the importance of multidisciplinary care in RVaO management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.126.049229","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:31:23Z","timestamp":1790310683000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Risk of Major Adverse Cardiovascular Events After Retinal Vascular Occlusions Versus Transient Ischemic Attack: A Propensity\u2010Score Matched Cohort Study"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1587-5368","authenticated-orcid":false,"given":"Chao\u2010Wei","family":"Chuang","sequence":"first","affiliation":[{"name":"Ditmanson Medical Foundation Chia\u2010Yi Christian Hospital","place":["Chiayi City, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8772-4073","authenticated-orcid":false,"given":"Cheng\u2010Yang","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Tainan Sin Lau Hospital","place":["Tainan, Taiwan"]},{"name":"Institute of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine, National Cheng Kung University","place":["Tainan, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6253-8813","authenticated-orcid":false,"given":"Sheng\u2010Feng","family":"Sung","sequence":"additional","affiliation":[{"name":"Ditmanson Medical Foundation Chia\u2010Yi Christian Hospital","place":["Chiayi City, Taiwan"]},{"name":"Fooyin University","place":["Kaohsiung, 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