{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:38:05Z","timestamp":1792647485925,"version":"4.5.0"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"20","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,10,20]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Diagnosing myocardial infarction in patients with prior coronary artery bypass grafting (CABG) remains challenging, primarily because of lower diagnostic accuracy of high\u2010sensitivity cardiac troponin (hs\u2010cTn). cMyC (cardiac myosin\u2010binding protein C), because of its faster release kinetics and greater abundance, may offer improved diagnostic performance in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">The diagnostic accuracy of cMyC was directly compared with that of hs\u2010cTnT and hs\u2010cTnI in a prospective, international, multicenter, diagnostic study enrolling adult patients presenting to the emergency department with acute chest discomfort. Final diagnoses were centrally adjudicated by 2 independent cardiologists using all available clinical and study\u2010specific data, including imaging and serial hs\u2010cTnT measurements. Patients were stratified according to the presence or absence of prior CABG.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Among 4752 patients, 387 (8%) had prior CABG (median age, 75\u2009years; 86% men). The incidence of myocardial infarction was significantly higher in patients with prior CABG (38% versus 16%;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001). In the CABG group, the diagnostic accuracy of cMyC as quantified by the area under the curve was 0.88 (95% CI, 0.85\u20130.92), which was comparable but not superior to that of hs\u2010cTnT (0.89 [95% CI, 0.86\u20130.92]) and hs\u2010cTnI (0.88 [95% CI, 0.84\u20130.91]). These findings were consistent across alternative high\u2010sensitivity cMyC assays.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">In patients with prior CABG, cMyC demonstrated high diagnostic accuracy for myocardial infarction, but not superior to established hs\u2010cTnT and hs\u2010cTnI assays.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Registration<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/clinicaltrials.gov\">clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique Identifier: NCT00470587.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.126.049244","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T12:06:40Z","timestamp":1791634000000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Cardiac Myosin\u2010Binding Protein C for Diagnosis of Myocardial Infarction in Patients With Prior Coronary Artery Bypass Grafting"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5934-0062","authenticated-orcid":false,"given":"Rebekka","family":"Odermatt","sequence":"first","affiliation":[{"name":"University Hospital Basel, University of Basel","place":["Basel, Switzerland"]},{"name":"GREAT Network","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2929-8600","authenticated-orcid":false,"given":"Luca","family":"Koechlin","sequence":"additional","affiliation":[{"name":"University Hospital 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