{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:38:56Z","timestamp":1792647536413,"version":"4.5.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"20","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,10,20]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Obesity is a growing risk factor for cardiovascular disease and mortality in the United States, particularly among younger adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Using the Centers for Disease Control and Prevention Wide\u2010Ranging Online Data for Epidemiologic Research Multiple Cause of Death database, we retrospectively analyzed trends and disparities in obesity\u2010related cardiac mortality among US individuals aged 15 to 44\u2009years from 1999 to 2023, stratified by sex, race, urbanization, and census region. Deaths were identified using\n                      <jats:italic toggle=\"no\">International Classification of Diseases, Tenth Revision<\/jats:italic>\n                      (\n                      <jats:italic toggle=\"no\">ICD\u201010<\/jats:italic>\n                      ) codes for obesity and cardiac conditions, including ischemic heart disease, sudden cardiac death, arrhythmias, and heart failure. Age\u2010adjusted mortality rates were calculated using joinpoint regression and expressed as annual percentage change with 95% CIs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">Between 1999 and 2023, 51\u2009860 obesity\u2010related cardiac deaths were recorded. The age\u2010adjusted mortality rates increased from 0.9 (95% CI, 0.8\u20130.9) to 2.5 (95% CI, 2.4\u20132.6) per 100\u2009000. Mortality was highest during the COVID\u201019 pandemic (2019\u20132021). Men consistently had higher age\u2010adjusted mortality rates than women. Black or African American and American Indian\/Alaska Native individuals showed the highest racial disparities. The South and nonmetropolitan areas had the highest regional mortality, with Alaska recording the highest state\u2010level age\u2010adjusted mortality rate in 2023 (6.0 per 100\u2009000). Mortality largely returned to baseline across most groups from 2021 to 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Obesity\u2010related cardiac mortality has risen in the United States over the past 2 decades with notable disparities across sex, race, region, and urbanization. These findings underscore the need for targeted public health interventions in high\u2010risk populations to reduce premature cardiovascular deaths and reverse this trend.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.126.049462","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T11:46:51Z","timestamp":1791632811000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Rising Obesity\u2010Driven Cardiac Mortality Among Young Adults in the United States: A 25\u2010Year Retrospective Analysis (1999\u20132023)"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7830-2737","authenticated-orcid":false,"given":"Megha","family":"Mohan","sequence":"first","affiliation":[{"name":"Government Medical College","place":["Kozhikode, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6176-4241","authenticated-orcid":false,"given":"Omer","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Government Medical College","place":["Kozhikode, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2659-6058","authenticated-orcid":false,"given":"Bakhtawara","family":"Alam","sequence":"additional","affiliation":[{"name":"Rehman Medical College","place":["Peshawar, Pakistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6361-5050","authenticated-orcid":false,"given":"Sidharth","family":"Narayanan","sequence":"additional","affiliation":[{"name":"Government Medical College","place":["Kozhikode, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6395-487X","authenticated-orcid":false,"given":"Basil Wahid","family":"Bhat","sequence":"additional","affiliation":[{"name":"Department of General Medicine, International Medical College and Hospital","place":["Dhaka, Bangladesh"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6757-8841","authenticated-orcid":false,"given":"Akiva","family":"Rosenzveig","sequence":"additional","affiliation":[{"name":"Cleveland Foundation","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7194-6328","authenticated-orcid":false,"given":"Aravinda","family":"Nanjundappa","sequence":"additional","affiliation":[{"name":"Cleveland Foundation","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelby","family":"Kutty","sequence":"additional","affiliation":[{"name":"BayCare Health System","place":["Clearwater, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","article-title":"Heterogeneous trends in burden of heart disease mortality by subtypes in the United States, 1999\u20132018: observational analysis of vital statistics","volume":"370","author":"Shah NS","year":"2020","unstructured":"Shah NS, Molsberry R, Rana JS, Sidney S, Capewell S, O'Flaherty M, Carnethon M, Lloyd\u2010Jones DM, Khan SS. 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