{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T14:32:07Z","timestamp":1793802727695,"version":"4.6.1"},"reference-count":71,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"20","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,10,20]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Patients with atherosclerotic cardiovascular disease (ASCVD) are at increased risk of pulmonary embolism (PE) and related mortality, yet contemporary US trends remain incompletely defined. We examined PE\u2010attributable mortality from 2010 to 2023 among patients with ASCVD, stratified by age, sex, race, ethnicity, urbanization, and region.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We used the Centers for Disease Control and Prevention's Wide\u2010Ranging Online Data for Epidemiologic Research data (2010\u20132023) to assess PE\u2010attributable mortality among patients with ASCVD aged \u226515\u2009years using age\u2010adjusted mortality rates. Concurrent trends in age\u2010adjusted ASCVD prevalence and risk factors were evaluated using NHANES (National Health and Nutrition Examination Survey). Age\u2010adjusted mortality rates were analyzed with Joinpoint regression to estimate average annual percentage change (95% CI), and trends in NHANES were assessed using linear models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      From 2010 to 2023, 152\u2009386 US patients with ASCVD aged \u226515\u2009years (80\u2009015 male, 72\u2009371 female) died from PE. PE\u2010attributable AAMR rose from 3.62 to 4.96 per 100\u2009000 (annual percentage change +3.1%;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001), with a modest increase from 2010 to 2018 (annual percentage change +0.7%,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.003) and a sharp rise from 2018 to 2023 (annual percentage change +12.8%,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001). Age\u2010adjusted mortality rate was highest in non\u2010Hispanic\/non\u2010Latinx Black American individuals, and American Indian\/Alaska Native and Hispanic\/Latinx populations had the steepest increases. Adults &lt;65\u2009years, rural areas, and the Western United States showed disproportionate rises, whereas the South had the highest absolute deaths. Such trends paralleled increasing ASCVD prevalence, which was driven by hypertension, obesity, diabetes, and chronic kidney disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">PE\u2010attributable mortality among US patients with ASCVD rose from 2010 to 2023 particularly among young\u2010to\u2010middle\u2010aged adults, socioeconomically isolated ethnic and racial groups, and Western residents.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.126.049510","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T11:23:20Z","timestamp":1792149800000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Pulmonary Embolism\u2010Attributable Mortality in Patients With Atherosclerotic Cardiovascular Disease in the United States from 2010 to 2023"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4559-1292","authenticated-orcid":false,"given":"Marco","family":"Zuin","sequence":"first","affiliation":[{"name":"University of Ferrara","place":["Ferrara, Italy"]},{"name":"University of Padova","place":["Padua, Italy"]},{"name":"University of Padua","place":["Padua, Italy"]},{"name":"AULSS 6, Ospedali Riuniti Padova Sud","place":["Monselice, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Bilato","sequence":"additional","affiliation":[{"name":"West Vicenza Hospitals","place":["Arzignano, Vicenza, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Rigatelli","sequence":"additional","affiliation":[{"name":"AULSS 6, Ospedali Riuniti Padova Sud","place":["Monselice, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6450-0448","authenticated-orcid":false,"given":"Samuel","family":"Goldhaber","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital Harvard Medical School","place":["Boston, USA"]},{"name":"Harvard Medical School","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1722-2983","authenticated-orcid":false,"given":"Gregory","family":"Piazza","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital Harvard Medical School","place":["Boston, USA"]},{"name":"Harvard Medical School","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa022157"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-59526-x"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.02096.x"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.113.302162"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13858"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.02121.x"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH14-06-0563"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2018.12.019"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.125.041420"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2018.4537"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpth.2023.100280"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-05-220491"},{"key":"e_1_3_1_14_2","unstructured":"https:\/\/wonder.cdc.gov\/ [Accessed January 5 2026]"},{"key":"e_1_3_1_15_2","unstructured":"https:\/\/www.cdc.gov\/nchs\/nhanes\/index.html [Accessed January 5 2026]"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.60315"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(19)30354-6"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.013744"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2018.5462"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2023.06.075"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2023.05.028"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpc.2020.100084"},{"key":"e_1_3_1_23_2","unstructured":"Census Bureau Population Division . 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