{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T06:17:21Z","timestamp":1788329841816,"version":"build-2803163510"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Sodium\u2010glucose cotransporter\u20102 (SGLT2) inhibitors reduce incident atrial fibrillation (AF), but their association with cerebrovascular and cardiovascular outcomes after AF diagnosis remains uncertain. We evaluated these outcomes in patients with newly diagnosed AF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Using Taiwan's National Health Insurance Research Database, we identified patients with newly diagnosed AF from 2013 through 2022. Regular SGLT2 inhibitor users were propensity score matched 1:10 to nonusers. The primary outcome was a composite of ischemic stroke, hemorrhagic stroke, or transient ischemic attack. Secondary outcomes were all\u2010cause mortality and major adverse cardiovascular events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Of 231\u2009030 eligible patients, 20\u2009911 were included in the matched analysis: 1901 users and 19\u2009010 nonusers (mean age, 72\u2009years; 41% women; mean CHA\n                      <jats:sub>2<\/jats:sub>\n                      DS\n                      <jats:sub>2<\/jats:sub>\n                      \u2010VASc\u00a0score, 3.7). Baseline SGLT2 inhibitor use was not significantly associated with the primary outcome (adjusted hazard ratio [HR], 0.90 [95% CI, 0.70\u20131.15];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.39), all\u2010cause mortality (adjusted HR, 0.95 [95% CI, 0.86\u20131.06];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.38), or major adverse cardiovascular events (adjusted HR, 0.94 [95% CI, 0.84\u20131.05];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.24). In a time\u2010dependent sensitivity analysis, current SGLT2 inhibitor exposure was associated with lower all\u2010cause mortality (adjusted HR, 0.71 [95% CI, 0.63\u20130.81];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Among patients with newly diagnosed AF, baseline SGLT2 inhibitor use was not significantly associated with lower risks of cerebrovascular events or major adverse cardiovascular events. The lower mortality observed in the time\u2010dependent analysis should be interpreted cautiously because of potential residual confounding. SGLT2 inhibitors should not be considered an alternative to guideline\u2010directed oral anticoagulation, which remains the cornerstone of stroke prevention in eligible patients with AF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.126.049649","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T11:54:32Z","timestamp":1787226872000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Sodium\u2010Glucose Cotransporter\u20102 Inhibition in Patients With Newly Diagnosed Atrial Fibrillation: A Nationwide Cohort Study"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6397-0843","authenticated-orcid":false,"given":"Ting\u2010Chun","family":"Huang","sequence":"first","affiliation":[{"name":"College of Medicine, National Cheng Kung University","place":["Tainan, Taiwan"]},{"name":"National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University","place":["Tainan, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9066-5302","authenticated-orcid":false,"given":"Li\u2010Hao","family":"Yap","sequence":"additional","affiliation":[{"name":"National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University","place":["Tainan, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7596-2958","authenticated-orcid":false,"given":"Hui\u2010Wen","family":"Lin","sequence":"additional","affiliation":[{"name":"National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University","place":["Tainan, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po\u2010Hsueh","family":"Su","sequence":"additional","affiliation":[{"name":"National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University","place":["Tainan, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Liao","sequence":"additional","affiliation":[{"name":"National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University","place":["Tainan, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0302-2347","authenticated-orcid":false,"given":"Chao\u2010Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University","place":["Tainan, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8722-3300","authenticated-orcid":false,"given":"Po\u2010Tseng","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Medicine, National Cheng Kung University","place":["Tainan, Taiwan"]},{"name":"National Cheng Kung University Hospital, College of Medicine, National Cheng Kung 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