{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T16:59:20Z","timestamp":1785257960284,"version":"3.55.0"},"reference-count":46,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"14","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,7,21]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Cardiovascular disease (CVD) is a leading cause of morbidity among cancer survivors. However, contemporary trends and independent association between cancer survivorship and prevalent CVD remain incompletely characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Using 2016 to 2024 Behavioral Risk Factor Surveillance System data, we analyzed 2 nationally representative cohorts of US adults. A trend cohort (n=3\u2009642\u2009415) assessed age\u2010standardized CVD prevalence via Joinpoint regression. An association cohort (n=829\u2009958) isolated the association between cancer survivorship and CVD using inverse probability of treatment weighting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      From 2016 to 2024, age\u2010standardized CVD prevalence among cancer survivors was persistently double that of the general population (12.9%\u201315.0% versus 6.8%), with no significant temporal decline. In unadjusted analysis to determine the absolute burden, survivors had 11.7% higher CVD prevalence than controls. After inverse probability of treatment weighting adjustment, a significant absolute prevalence difference of 3.0% persisted. Consequently, cancer survivorship was independently associated with prevalent CVD (odds ratio [OR], 1.22 [95% CI, 1.18\u20131.27=;\n                      <jats:italic toggle=\"no\">E<\/jats:italic>\n                      \u2010value=1.76). Associations were stronger among survivors aged &lt;65\u2009years (OR, 1.82 [95% CI, 1.58\u20132.08]) and those without traditional metabolic comorbidities (OR, 1.71 [95% CI, 1.50\u20131.95]). Site\u2010specific analyses revealed robust independent associations for prostate and colorectal cancers, whereas associations observed for breast and lung cancers were largely attenuated after adjustment for age and smoking\u2010related factors, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">The CVD burden among US cancer survivors remains persistently high. Independent of traditional factors, cancer survivorship is associated with a distinct cardiovascular burden, particularly among younger individuals and those with a low\u2010risk metabolic profile. These findings support extending cardiovascular surveillance to conventionally low\u2010risk subgroups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.126.049666","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T10:57:21Z","timestamp":1784285841000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Persistent Cardiovascular Burden and Independent Association Among Cancer Survivors in the United States, 2016 to 2024"],"prefix":"10.1161","volume":"15","author":[{"given":"Xinhui","family":"Liu","sequence":"first","affiliation":[{"name":"Qilu Hospital of Shandong University","place":["Jinan, China"]},{"name":"Chest Pain Center, Institute of Emergency and Critical Care Medicine of Shandong University, Qilu Hospital of Shandong University","place":["Jinan, China"]},{"name":"Qilu Hospital of Shandong University","place":["Jinan, 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