{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:53:47Z","timestamp":1791356027211,"version":"4.3.1"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"19","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,10,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">The increasing prevalence of atrial fibrillation (AF), along with changes in cardiovascular risk factors, AF detection and oral anticoagulant use, may have altered the epidemiology of AF\u2010related stroke. However, population\u2010based data on long\u2010term trends remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Using mandatory nationwide registry data from the Atrial Fibrillation in Norway (AFNOR) study\u00a0(2001\u20132021), we identified incident stroke cases defined as first hospitalization or death due to stroke in individuals aged \u226515\u2009years. Age\u2010standardized incidence rates were calculated using direct standardization. Sex\u2010 and age\u2010adjusted incidence rate ratios (IRR) were estimated using negative binomial regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">Among 227\u2009575 incident strokes, 66\u2009795 (29.4%) were AF\u2010related, and increased from 22% to 31% during 2001\u20132021, with 69% of all AF\u2010related ischemic strokes occurring in non\u2010anticoagulated individuals. Incidence rate of AF\u2010related ischemic strokes remained stable overall (67.8 per 100\u2009000 person\u2010years in 2001 to 68.4 in 2021; IRR=1.01; 95% CI, 1.00\u20131.03) but increased among individuals aged 15 to 64\u2009years. Non\u2010AF ischemic strokes declined from 204.4 to 130.8 (IRR=0.98; 95% CI, 0.97\u20130.99). Incidence of AF\u2010related intracerebral hemorrhage in individuals aged \u226575\u2009years increased, driven by anticoagulated patients. Incidence of non\u2010AF intracerebral hemorrhage decreased (IRR=0.98; 95% CI, 0.97\u20130.99).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">The favorable decline in ischemic stroke incidence from 2001 to 2021 did not include AF\u2010related strokes. AF\u2010related ischemic strokes increased in younger age groups, whereas AF\u2010related intracerebral hemorrhage increased in the oldest age groups driven by anticoagulated patients. These findings underscore the need for improved strategies for AF detection and stroke prevention, particularly in younger populations, and greater attention towards management of bleeding risk among older, anticoagulated individuals.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.126.049696","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T13:30:36Z","timestamp":1789738236000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Trends in Incidence of Atrial Fibrillation\u2013Related Stroke: The Norwegian AFNOR Study"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9480-3848","authenticated-orcid":false,"given":"Mariam","family":"Anjum","sequence":"first","affiliation":[{"name":"B\u00e6rum Hospital, Vestre Viken Hospital Trust","place":["Gjettum, Norway"]},{"name":"Institute of Clinical Medicine, University of 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