{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:38:14Z","timestamp":1792647494728,"version":"4.5.0"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"20","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,10,20]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Anthocyanins and anthocyanin\u2010rich berries have demonstrated lipid\u2010lowering and anti\u2010inflammatory effects; however, associations with cardiovascular disease remain mixed. We therefore examined anthocyanin and blueberry intake for prospective associations with cardiovascular disease risk and cross\u2010sectional associations with lipids and hs\u2010CRP (high\u2010sensitivity C\u2010reactive protein) in the WHS (Women's Health Study).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Among 38\u2009088 women who completed a baseline semiquantitative food frequency questionnaire in 1992 to 1995, we estimated intake of total anthocyanins, 6 anthocyanin subclasses, and blueberries. Multivariable hazard ratios (HRs) were calculated for confirmed major adverse cardiovascular events, including nonfatal myocardial infarction, nonfatal stroke, and cardiovascular disease death. In a subset of 26\u2009912 women with baseline blood samples, multivariable odds ratios were calculated for adverse lipid and hs\u2010CRP levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      During a median 28.0\u2010year follow\u2010up, 2752 major adverse cardiovascular event cases occurred. Age\u2010, energy\u2010, and WHS treatment\u2013adjusted HRs across quintiles of total anthocyanin intake were 1.00 (reference), 0.87 (95% CI, 0.78\u20130.98), 0.79 (95% CI, 0.70\u20130.89), 0.81 (95% CI, 0.72\u20130.91), and 0.88 (95% CI, 0.79\u20130.99) (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      \u2010trend=0.23). Further adjustment for clinical, lifestyle, and dietary factors showed no significant associations with major adverse cardiovascular events or their components, with similar null findings observed for anthocyanin subclasses and blueberries. In cross\u2010sectional analyses, higher total anthocyanins and anthocyanin subclasses, except pelargonidin, were significantly associated with lower multivariable\u2010adjusted odds of adverse high\u2010density lipoprotein cholesterol and triglycerides (all other\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      \u2010trend&lt;0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">In the WHS, anthocyanin and blueberry intake were not significantly associated with cardiovascular disease risk. However, higher anthocyanin intake was cross\u2010sectionally associated with lower odds of adverse high\u2010density lipoprotein cholesterol and triglycerides.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.126.049770","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T11:48:00Z","timestamp":1791632880000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Anthocyanin and Blueberry Intake, Lipids, C\u2010Reactive Protein, and the Risk of Cardiovascular Disease in Women"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1307-7165","authenticated-orcid":false,"given":"Sarah Jaehwa","family":"Park","sequence":"first","affiliation":[{"name":"Brigham and Women's Hospital and Harvard Medical School","place":["Boston, USA"]},{"name":"Osher Center for Integrative Health, Brigham and Women's Hospital and Harvard Medical School","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2129-8956","authenticated-orcid":false,"given":"Rikuta","family":"Hamaya","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital and Harvard Medical School","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1083-6907","authenticated-orcid":false,"given":"I\u2010Min","family":"Lee","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital and Harvard Medical School","place":["Boston, USA"]},{"name":"Harvard T.H. Chan School of Public Health","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie E.","family":"Buring","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital and Harvard Medical School","place":["Boston, USA"]},{"name":"Harvard T.H. 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