{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T14:31:37Z","timestamp":1793802697518,"version":"4.6.1"},"reference-count":67,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"20","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,10,20]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Cerebral small vessel disease (CSVD) is a heterogeneous disorder; however, interindividual variability in morphometric brain connectivity remains unclear, as does its association with gene expression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We enrolled 65 patients with CSVD and 35 healthy controls. Individual\u2010level morphometric brain networks were constructed from T1\u2010weighted magnetic resonance imaging, and intersubject variability of morphometric connectivity (IVMC) was quantified using a Kullback\u2013Leibler divergence\u2013based gray matter similarity measure. Group differences in IVMC and its associations with cognitive and clinical measures were examined. Partial least squares regression was applied to Allen Human Brain Atlas data to relate IVMC to gene expression, cell\u2010type specificity, and biological functions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Compared with healthy controls, patients with CSVD showed globally increased IVMC (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001) and significant differences across multiple functional networks (all P\n                      <jats:sub>False Discovery Rate<\/jats:sub>\n                      &lt;0.05). IVMC in the sensorimotor and ventral attention networks was associated with poorer Auditory\u2010Verbal Learning Test performance. Partial least squares regression analysis revealed that IVMC\u2010related genes were enriched in neurodevelopmental and metabolic processes, whereas negatively weighted genes were associated with synaptic structure and glutamatergic signaling. Cell\u2010type analyses linked IVMC alterations primarily to neuronal and glial transcriptional signatures.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">CSVD is associated with elevated IVMC across multiple functional networks, with changes in specific networks linked to memory impairment. These alterations may be associated with genes involved in neurodevelopment, synaptic function, and diverse neuronal and glial cell types, providing new insights into the interindividual variability of brain networks and the neurophysiological mechanisms underlying CSVD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.126.049778","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T11:54:42Z","timestamp":1791633282000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Altered Intersubject Variability of Morphological Connectivity in Cerebral Small Vessel Disease and Its Associations With Gene Expression and Cell Types"],"prefix":"10.1161","volume":"15","author":[{"given":"Jie","family":"Hu","sequence":"first","affiliation":[{"name":"The Second Affiliated Hospital of Anhui Medical University","place":["Hefei, China"]},{"name":"The First Affiliated Hospital of Anhui 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