{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:53:01Z","timestamp":1791355981458,"version":"4.3.1"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"19","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,10,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">The prevalence, anatomic distribution, enhancement patterns, and prognostic value of nonischemic late gadolinium enhancement (NI\u2010LGE) in patients with prior myocardial infarction were not systematically investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">A total of 948 patients (mean\u00b1SD age, 56.2\u00b110.9\u2009years; 88.4% men) diagnosed with prior myocardial infarction by cardiac magnetic resonance imaging were analyzed, excluding those with coexisting nonischemic cardiomyopathies or myocarditis. NI\u2010LGE was defined as midwall or subepicardial enhancement. Competing risk analysis was performed to mitigate the influence of competing events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Among these, NI\u2010LGE was observed in 78 patients (8.2%), with septal involvement present in all cases. Lower left ventricular ejection fraction (odds ratio [OR]=0.97,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.01) and larger end\u2010diastolic volume index (OR=1.01,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001) were independently associated with NI\u2010LGE. During a median follow\u2010up of 69.6 months (interquartile range, 49.7\u201380.9 months), 99 (10.4%) and 63 (6.6%) experienced heart failure (HF)\u2013 and sudden cardiac death\u2013related events, respectively. NI\u2010LGE was associated with a markedly increased risk of HF\u2010related events (subdistribution hazard ratio [sHR]=5.98,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001) after adjusting for the confounders, but not sudden cardiac death (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.65). NI\u2010LGE improved the model discrimination and fit performance (C\u2010index: 0.84\u20130.87; likelihood ratio: 1168.0\u20131106.1, both\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001) for the HF\u2010related events beyond left ventricular ejection fraction and late gadolinium enhancement extent. Moreover, NI\u2010LGE involving both the septum and free wall conferred a higher risk of HF\u2010related events than isolated septal involvement (sHR=2.42,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">NI\u2010LGE occurs in 8.2% of patients with prior myocardial infarction, predominantly involving the interventricular septum. As a potential marker of adverse remodeling, NI\u2010LGE might provide incremental prognostic value for HF\u2010related outcomes beyond traditional markers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.126.049783","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:43:17Z","timestamp":1790311397000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Septal Nonischemic Late Gadolinium Enhancement After Myocardial Infarction Is Associated With Adverse Remodeling and Improves Risk Stratification for Heart Failure Outcomes"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9719-067X","authenticated-orcid":false,"given":"Pengyu","family":"Zhou","sequence":"first","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, 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Sciences and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8807-5239","authenticated-orcid":false,"given":"Yun","family":"Tang","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8053-7120","authenticated-orcid":false,"given":"Zhuxin","family":"Wei","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5028-1475","authenticated-orcid":false,"given":"Xi","family":"Jia","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, 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