{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T00:12:01Z","timestamp":1793059921627,"version":"4.5.0"},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"14","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,7,21]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Mosaic loss of chromosome Y (mLOY) has been linked to several cardiovascular diseases, but its association with peripheral artery disease (PAD) remains unclear. We examined the relationship between mLOY and symptomatic PAD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      This longitudinal study included 217\u2009047 men without prevalent PAD. mLOY was identified using the Mosaic Chromosomal Alterations pipeline. Incident symptomatic PAD was ascertained using\n                      <jats:italic toggle=\"no\">International Classification of Diseases, Tenth Revision<\/jats:italic>\n                      (\n                      <jats:italic toggle=\"no\">ICD\u201010<\/jats:italic>\n                      ), and Office of Population Censuses and Surveys Classification of Interventions and Procedures, version 4 codes. Cox regression was used to evaluate the association between mLOY and PAD. We also performed exploratory mediation analyses of immune\u2010inflammatory biomarkers, examined the joint association of mLOY and smoking, and assessed the contribution of mLOY to sex\u2010related PAD disparities.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      During a median follow\u2010up of 13.6\u2009years, 4910 men developed symptomatic PAD. mLOY was associated with a higher risk of symptomatic PAD (hazard ratio [HR], 1.25 [95% CI, 1.17\u20131.33];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001), with the strongest association observed for expanded mLOY (mosaic cell fraction \u226510%) (HR, 1.35 [95% CI, 1.24\u20131.47];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001). Exploratory analyses suggested that several immune\u2010inflammatory biomarkers were statistically related to the mLOY\u2010PAD association. Additive\u2010scale interactions were observed between mLOY and former or current smoking. Compared with nonsmokers without mLOY, current smokers carrying mLOY had the highest PAD risk (HR, 4.69). Compared with matched women, men with mLOY had an \u22481.74\u2010fold higher PAD risk.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">mLOY was associated with symptomatic PAD, independently of other risk factors. These findings provide biologically informative evidence linking mLOY to symptomatic PAD and highlight smoking cessation as an important public\u2010health priority in men.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.126.049815","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T10:57:07Z","timestamp":1784285827000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Mosaic Loss of Chromosome Y, Smoking, and Risk of Symptomatic Peripheral Artery Disease: Insights From a Longitudinal Cohort Study"],"prefix":"10.1161","volume":"15","author":[{"given":"Jiahe","family":"Wei","sequence":"first","affiliation":[{"name":"Zhejiang University School of Medicine","place":["Hangzhou, 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China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9591-6991","authenticated-orcid":false,"given":"Ningjian","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai University of Medicine and Health Sciences","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3992-5812","authenticated-orcid":false,"given":"Xiao","family":"Tan","sequence":"additional","affiliation":[{"name":"Zhejiang University School of Medicine","place":["Hangzhou, China"]},{"name":"Uppsala University","place":["Uppsala, 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