{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T07:03:45Z","timestamp":1789715025049,"version":"4.0.1"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,5,19]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Elevated low\u2010density lipoprotein cholesterol (LDL\u2010C) is a risk factor for cardiovascular disease. Despite available lipid\u2010lowering therapies, lipid control remains suboptimal. Bempedoic acid offers a nonstatin oral treatment for hypercholesterolemia. However, real\u2010world data in Asia are limited. The study aimed to investigate the effectiveness and safety of bempedoic acid in Taiwan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">This prospective, pragmatic phase 4 study enrolled 180 patients with inadequately controlled hypercholesterolemia to receive bempedoic acid for 12\u2009weeks in addition to background lipid\u2010lowering therapy. The primary end point was the\u00a0percentage change in LDL\u2010C. Secondary end points included changes in other lipid parameters, hs\u2010CRP (high\u2010sensitivity C\u2010reactive protein), and safety outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Among 180 patients, 160 (88.9%) completed the study. The median percentage change in LDL\u2010C from baseline to week 12 was \u221219% (interquartile range, \u221236.4% to \u22123.6%), decreasing from 117.5 to 92\u2009mg\/dL (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.01). The median percentage changes from baseline to week 12 were \u221213.3% for non\u2013high\u2010density lipoprotein cholesterol, \u221210.8% for total cholesterol, \u221211.5% for apolipoprotein B, and \u221234.0% for hs\u2010CRP (all\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.01). Minimal effects were noted on triglycerides (0.2%), high\u2010density lipoprotein cholesterol (\u22125.5%), and lipoprotein(a) (2.6%) (all\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &gt;0.05). At week 12, 31.3% of patients achieved LDL\u2010C targets (&lt;100\u2009mg\/dL for primary prevention; and &lt;55 or &lt;70\u2009mg\/dL for secondary prevention). The safety outcomes were consistent with the locally approved label, with no new safety signals identified.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Bempedoic acid offers an effective and safe oral therapeutic option for Taiwanese patients whose LDL\u2010C levels remain inadequately controlled with existing lipid\u2010lowering therapy, including statins.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Registration<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/study\/NCT06925100\">https:\/\/clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique identifier: NCT06925100.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.126.049917","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T01:00:16Z","timestamp":1778806816000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Effectiveness and Safety of Bempedoic Acid in Taiwanese Patients With Hypercholesterolemia: A Pragmatic Phase 4 Study (CLEAR Taiwan Study)"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4621-9609","authenticated-orcid":false,"given":"I\u2010Chang","family":"Hsieh","sequence":"first","affiliation":[{"name":"Chang Gung Memorial Hospital, Linkou Branch","place":["Taoyuan, 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