{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T05:05:05Z","timestamp":1789535105234,"version":"build-2803163510"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"18","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,9,15]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Acute symptomatic seizures are common after pediatric ischemic stroke, but their associations with recovery, mortality, and later remote seizures, and the role of antiseizure medications, remain uncertain, especially in Chinese cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We analyzed a prospective multicenter cohort of children aged 29\u2009days to 18\u2009years with ischemic stroke enrolled in the CPISR (Chinese Pediatric Ischemic Stroke Registry) (January 2022\u2013May 2024). Exposures included acute seizures and antiseizure medications. Outcomes included Pediatric Stroke Outcome Measure at 90\u2009days and 1\u2009year, functional improvement, mortality, and poststroke epilepsy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">Among 562 children, 137 had acute seizures, including 30 with status epilepticus and 68 with multiple seizures. In fully adjusted models, status epilepticus was associated with poor 1\u2010year functional outcome (adjusted odds ratio [OR], 6.29 [95% CI, 2.10\u201319.09]) and higher odds of no functional improvement (adjusted OR, 2.90 [95% CI, 1.08\u20139.26]); multiple seizures were also associated with no functional improvement (adjusted OR, 2.33 [95% CI, 1.11\u20135.17]). In exploratory analyses, acute seizures were associated with worse Pediatric Stroke Outcome Measure subdomain scores at both 90\u2009days and 1\u2009year, whereas no independent association with all\u2010cause mortality was observed after full adjustment. Acute seizures were associated with an increased risk of poststroke epilepsy (adjusted hazard ratio, 5.52 [95% CI, 2.63\u201311.58]), particularly in children presenting with status epilepticus or multiple seizures. Prophylactic and early antiseizure medication use were not significantly associated with outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Acute status epilepticus and multiple seizures were associated with poorer recovery and higher risk of poststroke epilepsy, supporting risk stratification and targeted follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Registration<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.chictr.org.cn\/showprojEN.html?proj=169318\">https:\/\/www.chictr.org.cn<\/jats:ext-link>\n                      ; Unique identifier: ChiCTR2200059915.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.126.049931","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T14:51:56Z","timestamp":1788965516000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Associations of Acute Seizure Patterns With Functional Outcomes, Mortality, and Remote Seizures After Pediatric Ischemic Stroke"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0526-9218","authenticated-orcid":false,"given":"Yiran","family":"Dong","sequence":"first","affiliation":[{"name":"University of Science and Technology of China","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1699-9130","authenticated-orcid":false,"given":"Bin","family":"Zhu","sequence":"additional","affiliation":[{"name":"The 7th Medical Center of Chinese People's Liberation Army General Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0639-1695","authenticated-orcid":false,"given":"Wanqiu","family":"Zhang","sequence":"additional","affiliation":[{"name":"University of Science and Technology of China","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0280-1683","authenticated-orcid":false,"given":"Jinghui","family":"Zhong","sequence":"additional","affiliation":[{"name":"University of Science and Technology of China","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8182-9632","authenticated-orcid":false,"given":"Xinfeng","family":"Liu","sequence":"additional","affiliation":[{"name":"University of Science and Technology of China","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7268-2085","authenticated-orcid":false,"given":"Wen","family":"Sun","sequence":"additional","affiliation":[{"name":"University of Science and Technology of China","place":["Hefei, 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