{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:38:06Z","timestamp":1792647486825,"version":"4.5.0"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"20","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,10,20]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Anakinra is effective in recurrent pericarditis, yet optimal treatment duration and strategies for safe drug discontinuation remain uncertain. Identifying predictors of sustained remission after discontinuation is important for clinical management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We retrospectively analyzed 185 consecutive adult patients with corticosteroid\u2010dependent and colchicine\u2010resistant refractory recurrent pericarditis across 16 international referral centers, who permanently discontinued therapy after clinical remission. The primary end point was pericarditis recurrence after drug discontinuation. Univariate and multivariable Cox proportional hazards regression and Kaplan\u2010Meier analyses were performed to identify demographic, clinical, and therapeutic predictors of postdiscontinuation relapse.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Among 185 patients who discontinued anakinra (58.4% women, mean age 50.4\u00b117.8\u2009years, 77% idiopathic cause), treatment was initiated a median of 10\u2009months (interquartile range [IQR], 4.0\u201319.5) after the first episode and continued at 100 mg\/d for a median of 6\u2009months (IQR, 4\u201312). Over a median follow\u2010up of 7.2\u2009months (IQR, 1.5\u201323.3) after discontinuation, 68 patients (36.8%) experienced recurrence, with a median time to recurrence of 2.1\u2009months (IQR, 0.7\u20138.5). Initiation within 12\u2009months from the first pericarditis episode and maintenance of full\u2010dose therapy (100\u2009mg\/d) for \u22656\u2009months were independently associated with lower recurrence risk (hazard ratio [HR], 0.33 [95% CI, 0.18\u20130.66];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.001 and HR, 0.48 [95% CI, 0.23\u20130.86];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.017; respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Early initiation of anakinra and maintenance of full\u2010dose therapy for at least 6\u2009months are associated with a significantly lower risk of relapse after discontinuation and may inform treatment duration and discontinuation strategies in recurrent pericarditis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.126.050181","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T11:22:14Z","timestamp":1792149734000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Early Introduction and Prolonged Full\u2010Dose Anakinra Reduce Recurrence Risk After Discontinuation in Recurrent Pericarditis: An International Multicenter Cohort"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1053-5178","authenticated-orcid":false,"given":"Danilo","family":"Malandrino","sequence":"first","affiliation":[{"name":"University of Florence","place":["Florence, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Bettiol","sequence":"additional","affiliation":[{"name":"University of Florence","place":["Florence, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1203-000X","authenticated-orcid":false,"given":"Alessandro","family":"Andreis","sequence":"additional","affiliation":[{"name":"University Cardiology, AOU Citt\u00e0 della Salute e della Scienza di Torino","place":["Turin, Italy"]},{"name":"AOU Citt\u00e0 della Salute e della Scienza di Torino","place":["Turin, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4940-0876","authenticated-orcid":false,"given":"Gaetano M.","family":"De Ferrari","sequence":"additional","affiliation":[{"name":"University Cardiology, AOU Citt\u00e0 della Salute e della Scienza di Torino","place":["Turin, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Scudeler","sequence":"additional","affiliation":[{"name":"University Cardiology, AOU Citt\u00e0 della Salute e della Scienza di Torino","place":["Turin, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Agosti","sequence":"additional","affiliation":[{"name":"University Cardiology, AOU Citt\u00e0 della Salute e della Scienza di Torino","place":["Turin, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4901-5655","authenticated-orcid":false,"given":"Alida L. P.","family":"Caforio","sequence":"additional","affiliation":[{"name":"University of Padua","place":["Padua, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2643-4102","authenticated-orcid":false,"given":"Maria","family":"Canfora","sequence":"additional","affiliation":[{"name":"University of Florence","place":["Florence, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7352-1275","authenticated-orcid":false,"given":"Luca","family":"Cantarini","sequence":"additional","affiliation":[{"name":"University of Siena","place":["Siena, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreja C.","family":"Cercek","sequence":"additional","affiliation":[{"name":"University Medical Center Ljubljana","place":["Ljubljana, Slovenia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7428-315X","authenticated-orcid":false,"given":"Lorenzo","family":"Dagna","sequence":"additional","affiliation":[{"name":"Italy and Vita\u2010Salute San Raffaele University","place":["Milan, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1443-1840","authenticated-orcid":false,"given":"Antonella","family":"Insalaco","sequence":"additional","affiliation":[{"name":"Ospedale Pediatrico Bambino Ges\u00f9 IRCCS, ERN\u2010RITA Center","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0704-1916","authenticated-orcid":false,"given":"Marco","family":"Gattorno","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Giannina Gaslini","place":["Genoa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0131-7846","authenticated-orcid":false,"given":"Roberta","family":"Caorsi","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Giannina Gaslini","place":["Genoa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9240-8369","authenticated-orcid":false,"given":"Allan","family":"Klein","sequence":"additional","affiliation":[{"name":"Cleveland Clinic","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2802-9617","authenticated-orcid":false,"given":"George","family":"Lazaros","sequence":"additional","affiliation":[{"name":"National and Kapodistrian University of Athens School of Medicine","place":["Athens, Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4524-9566","authenticated-orcid":false,"given":"Giuseppe","family":"Lopalco","sequence":"additional","affiliation":[{"name":"University of Bari \u201cAldo Moro\u201d","place":["Bari, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9821-1225","authenticated-orcid":false,"given":"Sushil A.","family":"Luis","sequence":"additional","affiliation":[{"name":"Mayo Clinic","place":["Rochester, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9398-8366","authenticated-orcid":false,"given":"Silvia","family":"Maestroni","sequence":"additional","affiliation":[{"name":"Papa Giovanni XXIII Hospital","place":["Bergamo, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2995-6113","authenticated-orcid":false,"given":"Irene","family":"Mattioli","sequence":"additional","affiliation":[{"name":"University of Florence","place":["Florence, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1560-3907","authenticated-orcid":false,"given":"Raffaele","family":"Manna","sequence":"additional","affiliation":[{"name":"Universit\u00e0 Cattolica Sacro Cuore","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vartan","family":"Mardigyan","sequence":"additional","affiliation":[{"name":"Jewish General Hospital","place":["Montr\u00e9al, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Simonini","sequence":"additional","affiliation":[{"name":"Meyer Children's Hospital IRCCS","place":["Florence, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9719-2106","authenticated-orcid":false,"given":"Elena","family":"Silvestri","sequence":"additional","affiliation":[{"name":"University of Florence","place":["Florence, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Tavoni","sequence":"additional","affiliation":[{"name":"University of Pisa","place":["Pisa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5722-0245","authenticated-orcid":false,"given":"Massimo","family":"Imazio","sequence":"additional","affiliation":[{"name":"ASUFC, Piazzale Santa Maria della Misericordia","place":["Udine, Italy"]},{"name":"University of Udine","place":["Udine, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7566-5600","authenticated-orcid":false,"given":"Antonio","family":"Brucato","sequence":"additional","affiliation":[{"name":"University of Milan","place":["Milan, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9575-8321","authenticated-orcid":false,"given":"Giacomo","family":"Emmi","sequence":"additional","affiliation":[{"name":"Immunology and Allergy Service, University of Lausanne","place":["Lausanne, Switzerland"]},{"name":"Surgical and Health Sciences, University of Trieste","place":["Trieste, Italy"]},{"name":"Department of Medicine, Monash University, Monash Medical Centre","place":["Melbourne, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"De Benedetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilia","family":"Lazarou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovico Luca","family":"Sicignano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"De Matteis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Baritussio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Silvio","family":"Giordani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/eci.13392"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.17.1987"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.761064"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.38615"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.15826"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/2047487319879534"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2027892"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.032516"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/acr2.11776"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv318"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2025.05.023"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2020.04.006"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-024-01107-7"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes162"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.132508"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI141008"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kead381"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2024-225851"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2024.05.072"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaf192"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacasi.2024.08.006"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2024-324214"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.61610"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab452"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2024-325515"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2023-002599"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2020.11.016"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hjc.2026.04.006"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.126.050181","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:53:21Z","timestamp":1792644801000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.126.050181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,20]]},"references-count":28,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2026,10,20]]}},"alternative-id":["10.1161\/JAHA.126.050181"],"URL":"https:\/\/doi.org\/10.1161\/jaha.126.050181","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,20]]},"assertion":[{"value":"2026-02-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e050181"}}