{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:08:45Z","timestamp":1789013325838,"version":"build-2803163510"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,8,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Frailty is a multidimensional geriatric syndrome characterized by reduced physiological reserve and is consistently associated with adverse outcomes in cardiovascular diseases. Frailty has also been linked to poor short\u2010term prognosis in cerebrovascular disease. However, its association with long\u2010term functional recovery and stroke recurrence remains insufficiently established in large prospective cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We conducted a cohort study using data from the Impairment of Cognition and Sleep Study of the China National Stroke Registry III. Frailty was assessed at baseline using a deficit accumulation frailty index and categorized as robust, pre\u2010frail, or frail. Primary outcomes were 1\u2010year excellent functional outcome (modified Rankin Scale 0\u20131), favorable functional outcome (modified Rankin Scale 0\u20132), and stroke recurrence. Secondary outcomes were corresponding outcomes at 3 and 6 months. Associations were evaluated using multivariable logistic and Cox regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Among 2396 patients, 65.3% were robust, 18.0% pre\u2010frail, and 16.7% frail. Increasing frailty severity was independently associated with lower odds of 1\u2010year excellent functional outcome (pre\u2010frail: odds ratio [OR], 0.6; 95% CI, 0.4\u20130.8; frail: OR, 0.2; 95% CI, 0.2\u20130.3;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      for trend &lt;0.001). Frail patients also had higher stroke recurrence risk (hazard ratio [HR], 1.90; 95% CI, 1.33\u20132.71) and lower likelihood of favorable functional outcome. Similar dose\u2013response relationships were observed at 3 and 6 months, with consistent findings in sensitivity and subgroup analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Frailty is common after acute ischemic stroke and shows a strong, graded association with 1\u2010year functional recovery, supporting its potential value for long\u2010term prognostic stratification beyond age and comorbidity burden.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.126.050186","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T11:15:03Z","timestamp":1785496503000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Frailty and 1\u2010Year Prognosis of Patients With Ischemic Stroke: A Multicenter Cohort Study"],"prefix":"10.1161","volume":"15","author":[{"given":"Jiamin","family":"Xu","sequence":"first","affiliation":[{"name":"Capital Medical University","place":["Beijing, China"]},{"name":"Capital Medical University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyan","family":"Hu","sequence":"additional","affiliation":[{"name":"Capital Medical University","place":["Beijing, China"]},{"name":"Capital Medical University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9948-6869","authenticated-orcid":false,"given":"Xinying","family":"Huang","sequence":"additional","affiliation":[{"name":"Capital Medical University","place":["Beijing, China"]},{"name":"Capital Medical University","place":["Beijing, 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