{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:52:43Z","timestamp":1791355963072,"version":"4.3.1"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"19","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,10,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">The mortality risk of acute myocardial infarction declines rapidly after the initial period, yet the quantitative measures of residual risk in the follow\u2010up period remain limited. We aimed to assess restricted loss of life expectancy (LOLE) in patients with acute myocardial infarction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We included patients from KAMIR (Korea Acute Myocardial Infarction Registry), a nationwide acute myocardial infarction registry, between 2012 and 2020. The survival of 27\u2009705 patients (mean age, 64\u2009years; 76% men) was compared with an age\u2010, sex\u2010, and calendar year\u2013matched reference cohort derived from Korean population life tables. Three\u2010year restricted LOLE was estimated using a Royston\u2013Parmar flexible parametric survival model adjusted for clinical characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">Overall, 3\u2010year restricted LOLE was 23 (95% CI, 22\u201325) days. In subgroup analyses, older age (\u226575\u2009years, 42 [95% CI, 37\u201347] days versus &lt;50\u2009years, 7 [95% CI, 3\u201310] days), female sex (44 [95% CI, 37\u201351] days versus male sex, 14 [95% CI, 11\u201317] days), and lower left ventricular ejection fraction (\u226440%; 135 [95% CI, 128\u2013142] days versus \u226550%, 0 [\u22122 to 1] days) were associated with higher 3\u2010year restricted LOLE. Across the study period, 3\u2010year restricted LOLE nearly halved from 36 (95% CI, 31\u201341) to 16 (95% CI, 9\u201323) days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Restricted LOLE provides intuitive, patient\u2010centered measures of residual risk after acute myocardial infarction. It also demonstrated a significant improvements in patient outcomes over the study period.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.126.050187","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T16:45:07Z","timestamp":1788021907000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Restricted Loss of Life Expectancy in Patients With Acute Myocardial Infarction: A Nationwide KAMIR Registry Study"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4839-913X","authenticated-orcid":false,"given":"Jin\u2010Ho","family":"Choi","sequence":"first","affiliation":[{"name":"Sungkyunkwan University School of Medicine","place":["Seoul, Republic of 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