{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T14:31:23Z","timestamp":1793802683132,"version":"4.6.1"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      In nonischemic cardiomyopathy, the clinical relevance of decreased resting myocardial technetium\u201099m sestamibi (\n                      <jats:sup>99m<\/jats:sup>\n                      Tc\u2010MIBI) uptake regarding exercise capacity and clinical outcomes remains incompletely understood. We investigated whether decreased\n                      <jats:sup>99m<\/jats:sup>\n                      Tc\u2010MIBI uptake is associated with impaired exercise capacity and adverse clinical outcomes in nonischemic cardiomyopathy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      We retrospectively analyzed 182 patients (mean age 51.4\u00b114.0\u2009years; 27% female) with nonischemic cardiomyopathy and left ventricular ejection fraction &lt;50% who underwent\n                      <jats:sup>99m<\/jats:sup>\n                      Tc\u2010MIBI scintigraphy and cardiopulmonary exercise testing from 2016 to 2023. Myocardial uptake of\n                      <jats:sup>99m<\/jats:sup>\n                      Tc\u2010MIBI was evaluated using the summed rest score (SRS). Exercise capacity was assessed by percentage of predicted peak oxygen consumption (PPVO\n                      <jats:sub>2<\/jats:sub>\n                      ), with \u226460% defining impairment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Seventy\u2010four patients (41%) had PPVO\n                      <jats:sub>2<\/jats:sub>\n                      \u226460% and higher SRS (median: 12 versus 8;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      \u2009&lt;\u20090.001). Higher SRS remained significantly associated with PPVO\n                      <jats:sub>2<\/jats:sub>\n                      \u226460% after adjustment for relevant clinical covariates, including brain natriuretic peptide level, left ventricular ejection fraction, and heart failure duration. Over a median follow\u2010up of 807\u2009days, 23 patients (13%) experienced the composite outcome of all\u2010cause death, ventricular assist device implantation, or heart transplantation. Higher SRS was associated with composite outcomes after adjusting for PPVO\n                      <jats:sub>2<\/jats:sub>\n                      \u226460%. Among the 4 groups stratified by median SRS of 9 and PPVO\n                      <jats:sub>2<\/jats:sub>\n                      of 60%, patients with high SRS and low PPVO\n                      <jats:sub>2<\/jats:sub>\n                      had the highest incidence of adverse events.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Decreased myocardial\n                      <jats:sup>99m<\/jats:sup>\n                      Tc\u2010MIBI uptake was associated with impaired exercise capacity and adverse outcomes in patients with nonischemic cardiomyopathy. Our findings suggest that myocardial injury assessment using\n                      <jats:sup>99m<\/jats:sup>\n                      Tc\u2010MIBI scintigraphy may provide prognostic information complementary to exercise capacity.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.126.050214","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T11:16:16Z","timestamp":1787829376000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Summed Rest Score on Technetium\u201099m Sestamibi With Exercise Capacity and Incident Adverse Outcomes in Hospitalized Patients With Nonischemic Cardiomyopathy: A Retrospective Analysis"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7006-0007","authenticated-orcid":false,"given":"Hibiki","family":"Mima","sequence":"first","affiliation":[{"name":"The University of Osaka Graduate School of Medicine","place":["Osaka, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9260-6901","authenticated-orcid":false,"given":"Fusako","family":"Sera","sequence":"additional","affiliation":[{"name":"The University of Osaka Graduate School of Medicine","place":["Osaka, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2963-7895","authenticated-orcid":false,"given":"Tomohito","family":"Ohtani","sequence":"additional","affiliation":[{"name":"The University of Osaka Graduate School of Medicine","place":["Osaka, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0809-8714","authenticated-orcid":false,"given":"Yasuhiro","family":"Akazawa","sequence":"additional","affiliation":[{"name":"The University of Osaka Graduate School of Medicine","place":["Osaka, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6458-2685","authenticated-orcid":false,"given":"Shozo","family":"Konishi","sequence":"additional","affiliation":[{"name":"The University of Osaka Graduate School of Medicine","place":["Osaka, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3237-3293","authenticated-orcid":false,"given":"Takafumi","family":"Oka","sequence":"additional","affiliation":[{"name":"The University of Osaka Graduate School of Medicine","place":["Osaka, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5618-4721","authenticated-orcid":false,"given":"Yasushi","family":"Sakata","sequence":"additional","affiliation":[{"name":"The University of Osaka Graduate School of Medicine","place":["Osaka, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-007-0608-x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2009.09.010"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euw068"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.10.050"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.82.5.1826"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.94.5.1010"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2010.03.004"},{"key":"e_1_3_2_9_2","first-page":"527","article-title":"Gated myocardial SPECT to predict response to beta\u2010blocker therapy in patients with idiopathic dilated cardiomyopathy","volume":"45","author":"Fukuchi K","year":"2004","unstructured":"Fukuchi K, Yasumura Y, Kiso K, Hayashida K, Miyatake K, Ishida Y. 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