{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T05:05:40Z","timestamp":1789535140290,"version":"build-2803163510"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"18","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,9,15]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Coronary artery aneurysm (CAA) remains the most serious cardiovascular complication of Kawasaki disease. We sought to identify consistent risk factors for CAA among large contemporary cohorts from Japan and the United States.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      We conducted a retrospective cohort study including 42\u2009350 children from the 26th and 27th Japanese Nationwide Kawasaki Disease Surveys (2019\u20132022) and 1216 children from a multiethnic US cohort. Multivariable logistic regression was used to evaluate associations between clinical variables and CAA at 1\u2009month after disease onset (\n                      <jats:italic toggle=\"no\">Z<\/jats:italic>\n                      score \u22652.5).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      In both cohorts, baseline coronary artery dilation at diagnosis (\n                      <jats:italic toggle=\"no\">Z<\/jats:italic>\n                      score \u22652.5) was strongly associated with CAA 1\u2009month after disease onset (Japan: odds ratio [OR], 22.7 [95% CI, 19.2\u201326.7]; United States: OR, 13.4 [95% CI, 8.6\u201321.0]). Age younger than 6 months and intravenous immunoglobulin resistance were also independently associated with increased risk. These associations were also observed for medium to giant CAAs. Stratified analyses demonstrated that intravenous immunoglobulin resistance was most strongly associated with subsequent CAA among children with normal coronary arteries at diagnosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Among large Japanese and US cohorts, coronary artery dilation at diagnosis and age younger than 6 months were consistent predictors of CAA. These associations were also observed for medium to giant CAA, underscoring their relevance for clinically significant coronary outcomes. Early coronary artery assessment provides important prognostic information and may inform cardiovascular risk stratification and management in children with Kawasaki disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.126.050238","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T14:48:41Z","timestamp":1788965321000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Risk Factors for Coronary Artery Aneurysms in Children With Kawasaki Disease"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5808-7709","authenticated-orcid":false,"given":"Shoko","family":"Yamazaki","sequence":"first","affiliation":[{"name":"University of California San Diego","place":["La Jolla, USA"]},{"name":"Shinshu University School of Medicine","place":["Nagano, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2049-5309","authenticated-orcid":false,"given":"Koichi","family":"Miyata","sequence":"additional","affiliation":[{"name":"University of California San Diego","place":["La Jolla, USA"]},{"name":"Ota Memorial Hospital","place":["Gunma, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Sun","sequence":"additional","affiliation":[{"name":"University of California San Diego","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3149-2699","authenticated-orcid":false,"given":"Chisato","family":"Shimizu","sequence":"additional","affiliation":[{"name":"University of California San Diego","place":["La Jolla, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2660-530X","authenticated-orcid":false,"given":"Ryusuke","family":"Ae","sequence":"additional","affiliation":[{"name":"Jichi Medical University","place":["Tochigi, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9484-4770","authenticated-orcid":false,"given":"Kirsten B.","family":"Dummer","sequence":"additional","affiliation":[{"name":"University of California San Diego","place":["La Jolla, USA"]},{"name":"Rady Children's Hospital San Diego","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9537-175X","authenticated-orcid":false,"given":"Adriana H.","family":"Tremoulet","sequence":"additional","affiliation":[{"name":"University of California San Diego","place":["La Jolla, USA"]},{"name":"Rady Children's Hospital San Diego","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5679-1217","authenticated-orcid":false,"given":"Jane C.","family":"Burns","sequence":"additional","affiliation":[{"name":"University of California San Diego","place":["La Jolla, USA"]},{"name":"Rady Children's Hospital San Diego","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8408-1247","authenticated-orcid":false,"given":"Sonia","family":"Jain","sequence":"additional","affiliation":[{"name":"University of California San Diego","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","first-page":"178","article-title":"Acute febrile mucocutaneous syndrome with lymphoid involvement with specific desquamation of the fingers and toes in children","volume":"16","author":"Kawasaki T","year":"1967","unstructured":"Kawasaki T. 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