{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T05:04:37Z","timestamp":1789535077585,"version":"build-2803163510"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"18","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,9,15]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Intracranial atherosclerotic stenosis (ICAS) is a major cause of ischemic stroke with a high recurrence risk despite guideline\u2010based secondary prevention. Although inflammation may contribute to this residual risk, the prognostic roles of interleukin\u20106 (IL\u20106) and hsCRP (high\u2010sensitivity C\u2010reactive protein) in ICAS\u2010related stroke remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">This prospective observational study enrolled 942 patients with ischemic stroke within 1\u2009week of onset. ICAS was defined as \u226550% stenosis\/occlusion. High IL\u20106 and hsCRP levels were defined using median cutoffs of \u22654.2\u2009pg\/mL and \u22652.0\u2009mg\/L, respectively. The primary end point was 1\u2010year major adverse cardiovascular events (MACE), including nonfatal stroke, nonfatal acute coronary syndrome, and vascular death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Of the 942 patients (mean age; 71.2\u2009years, men; 61.3%), 262 (27.8%) had ICAS. Among patients with ICAS, elevated IL\u20106 and hsCRP were each associated with higher MACE rates (IL\u20106: 15.4% versus 28.8%, log\u2010rank\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.012; hsCRP: 15.9% versus 28.5%, log\u2010rank\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.015). After multivariate adjustment, hsCRP \u22652.0\u2009mg\/L remained independently associated with MACE (hazard ratio [HR], 2.01; 95% CI, 1.12\u20133.59), whereas the association for IL\u20106\u22654.2\u2009pg\/mL was attenuated (HR, 1.75; 95% CI, 0.95\u20133.23). Both biomarkers were associated with MACE in patients achieving low\u2010density lipoprotein cholesterol &lt;100\u2009mg\/dL. Receiver operating characteristic\u2013derived cutoffs of 5.0\u2009pg\/mL for IL\u20106 and 2.9\u2009mg\/L for hsCRP independently predicted MACE (HR, 2.02 and 2.86, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Baseline hsCRP may improve risk stratification in ICAS\u2010related stroke by identifying residual inflammatory risk beyond conventional risk factors. The prognostic value of IL\u20106 was less robust and requires further investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.126.050279","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T14:49:35Z","timestamp":1788965375000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Value of Interleukin\u20106 and High\u2010Sensitivity C\u2010Reactive Protein in Stroke Associated With Intracranial Atherosclerotic Stenosis"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2477-9755","authenticated-orcid":false,"given":"Takao","family":"Hoshino","sequence":"first","affiliation":[{"name":"Tokyo Women's Medical University Hospital","place":["Tokyo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5199-4293","authenticated-orcid":false,"given":"Takafumi","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Tokyo Women's Medical University Hospital","place":["Tokyo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1636-7184","authenticated-orcid":false,"given":"Satoko","family":"Arai","sequence":"additional","affiliation":[{"name":"Tokyo Women's Medical University Hospital","place":["Tokyo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2817-9119","authenticated-orcid":false,"given":"Megumi","family":"Hosoya","sequence":"additional","affiliation":[{"name":"Tokyo Women's Medical University Hospital","place":["Tokyo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuntaro","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Tokyo Women's Medical University Hospital","place":["Tokyo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Wako","sequence":"additional","affiliation":[{"name":"Tokyo Women's Medical University Hospital","place":["Tokyo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9571-7148","authenticated-orcid":false,"given":"Kentaro","family":"Ishizuka","sequence":"additional","affiliation":[{"name":"Tokyo Women's Medical University Hospital","place":["Tokyo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1990-4707","authenticated-orcid":false,"given":"Sono","family":"Toi","sequence":"additional","affiliation":[{"name":"Tokyo Women's Medical University Hospital","place":["Tokyo, Japan"]},{"name":"Tokyo Women's Medical University Adachi Medical Center","place":["Tokyo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Todo","sequence":"additional","affiliation":[{"name":"Tokyo Women's Medical University Hospital","place":["Tokyo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.123.043630"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30079-X"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1105335"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.1693"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000375"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199901143400207"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.122.040529"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.5551\/jat.65842"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000089920.93927.A7"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.5551\/jat.64229"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.045256"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000200112"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)09292-1"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2007.05.013"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2023.01.004"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/23969873251317341"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/svn-2023-002421"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1912388"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2021372"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00968-1"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2023-079061"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000214214"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2025.2033"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.126.050279","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T04:32:57Z","timestamp":1789533177000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.126.050279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,15]]},"references-count":23,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2026,9,15]]}},"alternative-id":["10.1161\/JAHA.126.050279"],"URL":"https:\/\/doi.org\/10.1161\/jaha.126.050279","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,15]]},"assertion":[{"value":"2026-02-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e050279"}}