{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T14:31:19Z","timestamp":1793802679064,"version":"4.6.1"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Transcatheter edge\u2010to\u2010edge repair (TEER) and replacement (TTVR) have emerged as new modalities to treat patients with symptomatic significant tricuspid regurgitation. This study aimed to compare invasive hemodynamic and right ventricular (RV) changes and symptom improvement over 1 year.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Patients who underwent TEER\/TTVR at Mayo Clinic (Rochester, MN, 2017\u20132024) were included. Hemodynamic profiles were described before and immediately after intervention, in addition to RV enlargement\/dysfunction \u2265moderate at 30\u2009days and change in symptoms over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Of 100 patients included (50 per group, median age 81 versus 80\u2009years and female 62% versus 42%, in TTVR and TEER, respectively), all had \u2265 moderate\u2013severe symptomatic tricuspid regurgitation. Post intervention, mean right atrial pressure decreased in TEER (16 to 14\u2009mm Hg,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001), V wave decreased in both groups (to 16\u2009mm Hg,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001). RV enlargement was less prevalent in both cohorts at 30\u2009days (60%\u201340% in TEER,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.01, and 72 to 58% in TTVR,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.07), yet prevalence of RV dysfunction decreased only in TEER (26 to 15%,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.17) as opposed to TTVR (31 to 44%,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.13). TTVR resulted in a higher stroke volume index and more complete tricuspid regurgitation elimination at 30\u2009days. Both groups resulted in similar improvements in New York Heart Association class, with overall similar survival.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">TEER was associated with a greater reduction in right atrial pressure and more favorable RV remodeling at 30\u2009days, as opposed to TTVR, which achieved more complete and sustained elimination of tricuspid regurgitation with higher forward stroke volume.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.126.050310","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T11:16:19Z","timestamp":1787829379000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Hemodynamic Changes After Transcatheter Valve Repair and Replacement for Tricuspid Regurgitation"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7632-666X","authenticated-orcid":false,"given":"Mohamad S.","family":"Alabdaljabar","sequence":"first","affiliation":[{"name":"Mayo Clinic","place":["Rochester, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7966-7224","authenticated-orcid":false,"given":"Mohamed","family":"Elhadi","sequence":"additional","affiliation":[{"name":"Mayo Clinic","place":["Rochester, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4489-2349","authenticated-orcid":false,"given":"Jeremy J.","family":"Thaden","sequence":"additional","affiliation":[{"name":"Mayo Clinic","place":["Rochester, 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