{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:22:22Z","timestamp":1790140942992,"version":"4.0.1"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"14","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,7,21]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Inherited cardiomyopathies cause ventricular tachycardia (VT) and heart failure, yet genotype\u2010based substrate characterization is limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Patients with inherited cardiomyopathy undergoing VT (n=80) or premature ventricular complex (n=25) ablation between 2010 and 2024 were evaluated for arrhythmia substrate, ablation, and heart failure outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Among 105 patients, the median age was 51\u2009years, 72% were men, and the cohort comprised desmosomal (desmoplakin [DSP], 11%; non\u2010DSP, 24%), titin (22%), lamin A\/C (LMNA; 20%), sarcomeric (14%), ion\u2010channel (5%), and cytoskeletal\/Z\u2010disk (4%) genotype groups. In the VT cohort, low\u2010voltage substrate was predominantly septal in the LMNA (55%), titin (67%), and sarcomeric (75%) groups; both septal (75%) and lateral left ventricle (75%) in the cytoskeletal\/Z\u2010disk group; perimitral (71%) and lateral left ventricle (57%) in the DSP desmosomal group; and right ventricular free wall (91%) in the non\u2010DSP desmosomal group. Ablation eliminated clinical VT in 90%, with noninducibility of any VT in 52 of 80 (65%) cases. VT\u2010free survival was 51% during 3\u2009years (1.8\u20136.3\u2009years). Among recurrences, 11 of 39 (28%) patients had a single VT episode. VT\u2010free survival was highest in the non\u2010DSP desmosomal group and lowest in the LMNA group (66% versus 20%,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.03). Residual VT inducibility (hazard ratio [HR], 2 [95% CI, 1.05\u20133.77]) and\n                      <jats:italic toggle=\"no\">LMNA<\/jats:italic>\n                      variant (HR, 2.25 [95% CI, 1.1\u20134.57]) predicted recurrence. In the premature ventricular complex cohort, the burden decreased from 12% (interquartile range [IQR]=Q3\u2013Q1, 21\u20138) to 3.75% (IQR 3\u20131, 6\u20131), and 17 of 25 (68%) had \u22645% burden. End\u2010stage heart failure outcome (left ventricular assist device, transplant, or death) occurred in 29% overall and 52% in the LMNA group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Genotype correlates with VT substrate. Ablation successfully reduced VT and premature ventricular complex burden; however, long\u2010term VT recurrence was common except in non\u2010DSP desmosomal variants. LMNA variants portend worse outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.126.050508","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T10:52:36Z","timestamp":1784285556000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Ventricular Arrhythmia Ablation in Inherited Cardiomyopathy: Phenotype Variability and Outcomes Based on Functional Genotypes"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9576-5978","authenticated-orcid":false,"given":"Arian","family":"Afzalian","sequence":"first","affiliation":[{"name":"University of Pennsylvania","place":["Philadelphia, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2422-2930","authenticated-orcid":false,"given":"Alireza","family":"Oraii","sequence":"additional","affiliation":[{"name":"University of 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