{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:53:18Z","timestamp":1791355998289,"version":"4.3.1"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"19","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,10,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">The Aveir leadless pacemaker uses an active fixation method, enabling real\u2010time monitoring of electrical parameters during implantation. However, comprehensive studies on the electrical parameters during this procedure are rare. This study aims to analyze the electrical characteristics to further guide the implantation strategy and improve device stability and safety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">This multicenter retrospective study enrolled 119 patients (mean age, 70.18\u2009years; 59.58% women) who received the Aveir VR leadless pacemaker from November 2024 to May 2025 at 10 centers in China. Intraprocedural variations in commanded electrogram, current of injury (COI), impedance, pacing threshold, and sensing parameters were meticulously documented.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Commanded electrogram mapping demonstrated various morphologies (R, RS, QR, QRS, and QS), aiding localization. During fixation, 58.82% of patients exhibited an increased COI from mapping to 0.5 turns, which was associated with reduced short\u2010term pacing thresholds. From 0.5 to 1 turn, 52.94% showed a further increase in COI. Receiver operating characteristic analysis revealed that an impedance increase has predictive value for short\u2010term pacing thresholds, with an area under the receiver operating characteristic curve of 0.634 and a cutoff value of 230\u2009\u03a9 (sensitivity, 0.622; specificity, 0.41). Lead stability showed a moderate correlation with impedance increase (\n                      <jats:italic toggle=\"no\">R<\/jats:italic>\n                      =0.44,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001), while the correlation with COI was weak.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">During Aveir implantation, commanded electrogram variations guide site localization. Initial COI increases (0\u20130.5 turns) are linked to optimal short\u2010term thresholds. Monitoring impedance increase is vital, as a threshold of 230\u2009\u03a9 serves as a key indicator of device stability and fixation quality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.126.050579","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T13:29:00Z","timestamp":1789738140000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Multicenter Study of the Electrical Characteristics and Short\u2010Term Outcomes of the Aveir VR Leadless Pacemaker"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5136-3774","authenticated-orcid":false,"given":"Jian\u2010du","family":"Yang","sequence":"first","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0608-524X","authenticated-orcid":false,"given":"Ruo\u2010gu","family":"Li","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing\u2010bin","family":"Liu","sequence":"additional","affiliation":[{"name":"West China Hospital of Sichuan University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010lin","family":"Xue","sequence":"additional","affiliation":[{"name":"Xi'an Jiaotong University","place":["Xi\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5220-3972","authenticated-orcid":false,"given":"Jiang\u2010hua","family":"Zhang","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Xinjiang Medical University","place":["Xinjiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong\u2010mei","family":"Hu","sequence":"additional","affiliation":[{"name":"The Second People's Hospital of Chengdu","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5957-121X","authenticated-orcid":false,"given":"Bao\u2010jian","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Department of Cardiology, Affiliated Hospital of Traditional Chinese Medicine of Xinjiang Medical University","place":["Urumqi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Tong","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Southwest Jiaotong University","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0786-5771","authenticated-orcid":false,"given":"Hui","family":"Luo","sequence":"additional","affiliation":[{"name":"Changsha First Hospital","place":["Changsha, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Shen","sequence":"additional","affiliation":[{"name":"Fourth Military Medical University","place":["Shaanxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3135-2669","authenticated-orcid":false,"given":"Zhong\u2010li","family":"Chen","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiahenazi","family":"Aiyasiding","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng\u2010xing","family":"Cai","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojian","family":"Chi","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Dai","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4845-8091","authenticated-orcid":false,"given":"Baopeng","family":"Tang","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Xinjiang Medical University","place":["Xinjiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3848-179X","authenticated-orcid":false,"given":"Ke\u2010ping","family":"Chen","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.04.043"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1714\/3824.38087"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2018.04.027"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1604852"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2021.11.002"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2308513"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.10.045"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euw346"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2022.04.027"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euae051"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.126.050579","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:25:47Z","timestamp":1791354347000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.126.050579"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,6]]},"references-count":10,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2026,10,6]]}},"alternative-id":["10.1161\/JAHA.126.050579"],"URL":"https:\/\/doi.org\/10.1161\/jaha.126.050579","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,6]]},"assertion":[{"value":"2026-03-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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