{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:38:05Z","timestamp":1792647485972,"version":"4.5.0"},"reference-count":71,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"20","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,10,20]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Childhood obesity is a major public health concern that increases cardiovascular disease (CVD) risk. The Developmental Origins of Health and Disease theory posits that obesity and CVD risk is, in part, programmed in utero. A greater understanding of modifiable maternal factors that associate with offspring obesity and CVD risk in childhood could inform primordial prevention interventions during pregnancy. Maternal sedentary behavior, physical activity, and sleep during pregnancy are modifiable and plausible determinants of offspring obesity and CVD risk yet remain insufficiently studied. This protocol describes the design of the Pregnancy 24\/7 Offspring Study (NCT07172880), developed to address this gap in knowledge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">This study examines associations between device\u2010based maternal 24\u2010hour movement behavior (sedentary behavior, physical activity, and sleep) measured in each pregnancy trimester and analyzed via trajectories and as compositions with offspring obesity and CVD risk through 24 months of age. Maternal 24\u2010hour movement behavior data and birth outcomes were previously collected in the Pregnancy 24\/7 Cohort Study (N=500, Iowa, Pennsylvania, and West Virginia). The Offspring study extends this cohort by enrolling up to 450 maternal\u2010offspring dyads and collecting new measures in the offspring, including body mass index z\u2010score from birth through 24 months obtained via medical record abstraction, anthropometry, indicators of CVD risk, and maternal questionnaires. The primary outcome is body mass index z\u2010score trajectory; secondary outcomes include adiposity, blood pressure, and brachial\u2010femoral pulse wave velocity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Findings from this study will advance understanding of how maternal 24\u2010hour activity associates with early\u2010life obesity and CVD risk, informing primordial prevention strategies during pregnancy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.126.050797","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T11:47:29Z","timestamp":1791632849000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Sedentary Behavior, Physical Activity, and Sleep During Pregnancy and Offspring Health: Protocol for the Pregnancy 24\/7 Offspring Multi\u2010Site Cohort Study"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2343-4162","authenticated-orcid":false,"given":"Kara M.","family":"Whitaker","sequence":"first","affiliation":[{"name":"University of Iowa","place":["Iowa City, USA"]},{"name":"University of Iowa","place":["Iowa City, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7919-5247","authenticated-orcid":false,"given":"Melissa A.","family":"Jones","sequence":"additional","affiliation":[{"name":"Oakland University","place":["Rochester, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4683-9576","authenticated-orcid":false,"given":"Alex H.","family":"Crisp","sequence":"additional","affiliation":[{"name":"University of Iowa","place":["Iowa City, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3788-5856","authenticated-orcid":false,"given":"Jaemyung","family":"Kim","sequence":"additional","affiliation":[{"name":"University of Iowa","place":["Iowa City, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3556-598X","authenticated-orcid":false,"given":"Sharon E.","family":"Taverno Ross","sequence":"additional","affiliation":[{"name":"University of Pittsburgh","place":["Pittsburgh, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5763-8385","authenticated-orcid":false,"given":"Brooke N.","family":"Anthos","sequence":"additional","affiliation":[{"name":"University of Iowa","place":["Iowa City, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor","family":"Marske","sequence":"additional","affiliation":[{"name":"University of Iowa","place":["Iowa City, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabera","family":"Rahman","sequence":"additional","affiliation":[{"name":"University of Pittsburgh","place":["Pittsburgh, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6369-7802","authenticated-orcid":false,"given":"J. 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