{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T06:17:47Z","timestamp":1788329867614,"version":"build-2803163510"},"reference-count":90,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Prognosis after myocardial infarction (MI) remains heterogeneous despite contemporary reperfusion and secondary prevention, and biomarkers that capture post\u2010MI recovery, treatment response, and long\u2010term risk are still limited. Noncoding RNAs have therefore attracted interest as biomarkers of post\u2010MI risk and recovery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We conducted a scoping review of human studies evaluating circulating or blood\u2010derived noncoding RNAs, including microRNAs, long noncoding RNAs, circular RNAs, and tRNA\u2010derived small RNAs\/tRNA\u2010derived fragments, measured after MI in relation to prognostic phenotypes, clinical outcomes, or treatment\u2010response end points.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Forty\u2010six studies were included. Most were observational, focused on plasma or serum microRNAs, and used quantitative reverse transcription\u2013polymerase chain reaction, but sample size, sampling phase, normalization strategy, end point definition, follow\u2010up duration, and validation approaches varied substantially. Reported associations clustered around reperfusion\u2010related injury\/no reflow or microvascular obstruction, left ventricular remodeling or dysfunction, clinical events, including major adverse cardiovascular events and mortality, and a smaller group of treatment\u2010response phenotypes. Directional signals included miR\u201030e, miR\u2010660\u20105p,\n                      <jats:italic toggle=\"yes\">TUG1<\/jats:italic>\n                      , and\n                      <jats:italic toggle=\"yes\">MALAT1<\/jats:italic>\n                      for no reflow;\n                      <jats:italic toggle=\"yes\">LIPCAR<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">MICRA<\/jats:italic>\n                      , miR\u2010320a, miR\u20101254, and miR\u201022\u20103p for remodeling or ventricular recovery; miR\u2010145, miR\u2010223\u20103p, miR\u2010126\u20103p\/miR\u2010223\u20103p,\n                      <jats:italic toggle=\"yes\">HCG11<\/jats:italic>\n                      \/miR\u2010532\u20103p, and exosomal miR\u2010186\u20105p dynamics for clinical events; and\n                      <jats:italic toggle=\"yes\">BANCR<\/jats:italic>\n                      or selected tRNA\u2010derived small RNAs\/tRNA\u2010derived fragments for treatment\u2010response heterogeneity. The most plausible candidates were phenotype specific rather than universal, with event\u2010related microRNA models, imaging\u2010linked remodeling markers, and no\u2010reflow\/microvascular obstruction\u2013associated candidates appearing more mature than isolated injury\u2010linked diagnostic microRNAs or single\u2010study treatment\u2010response signals.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Overall, noncoding RNAs show promise as adjunctive post\u2010MI biomarkers, but clinical translation requires phase\u2010aligned sampling, assay standardization, external validation, and direct testing of incremental value beyond established clinical, imaging, and protein\u2010biomarker models.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.126.050885","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T11:32:11Z","timestamp":1787225531000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Noncoding RNAs as Prognostic Biomarkers After Myocardial Infarction: A Scoping Review"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1429-4128","authenticated-orcid":false,"given":"\u0141ukasz","family":"Wi\u00b4niowski","sequence":"first","affiliation":[{"name":"Medical University of Lublin","place":["Lublin, Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4040-8068","authenticated-orcid":false,"given":"Maciej","family":"Biskupski","sequence":"additional","affiliation":[{"name":"Medical University of Lublin","place":["Lublin, Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1853-5006","authenticated-orcid":false,"given":"Robert","family":"B\u0142aszczyk","sequence":"additional","affiliation":[{"name":"Medical University of Lublin","place":["Lublin, Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2718-4300","authenticated-orcid":false,"given":"Bartosz","family":"Kondracki","sequence":"additional","affiliation":[{"name":"Medical University of Lublin","place":["Lublin, Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4358-386X","authenticated-orcid":false,"given":"Jan","family":"Siwiec","sequence":"additional","affiliation":[{"name":"Medical University of Lublin","place":["Lublin, Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7399-8340","authenticated-orcid":false,"given":"Rados\u0142aw","family":"Mlak","sequence":"additional","affiliation":[{"name":"Medical University of Lublin","place":["Lublin, Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"G\u0142owniak","sequence":"additional","affiliation":[{"name":"Medical University of Lublin","place":["Lublin, Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","volume-title":"Cardiovascular diseases (CVDS)","year":"2025","unstructured":"Cardiovascular diseases (CVDS). 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