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Despite growing recognition, evidence\u2010based management strategies remain limited due to the absence of randomized controlled trials. However, early evidence from small randomized trials is emerging in support of nonpharmacological interventions. This review provides a comprehensive synthesis of current therapeutic strategies for acute and long\u2010term management of TTS, including pharmacological and nonpharmacological interventions such as cardiac rehabilitation, and management of psychiatric (eg, anxiety, depression) comorbidities, which increase the incidence of recurrences. As of today, TTS management remains largely empirical, relying on expert consensus and registry data focused on a multidisciplinary, personalized approach integrating cardiovascular, neurological, and psychological domains. 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