{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:53:51Z","timestamp":1791356031443,"version":"4.3.1"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"19","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,10,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Obstructive sleep apnea is associated with left atrial enlargement, a predictor of stroke. We hypothesized that continuous positive airway pressure (CPAP) would reduce the left atrial volume index (LAVI) and modify its longitudinal trajectory in patients with stroke and obstructive sleep apnea.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Patients with stroke and obstructive sleep apnea were randomized to standard care plus CPAP or standard care alone. Coprimary outcomes were absolute 12\u2010month change and longitudinal trajectories of LAVI and N\u2010terminal pro\u2010B\u2010type natriuretic peptide (NT\u2010proBNP), assessed at baseline and 3, 6, and 12\u2009months. Functional outcomes were assessed at 3, 6, and 12\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Seventy\u2010one participants were randomized (35 CPAP, 36 control). LAVI did not change significantly from baseline to 12\u2009months in either group, and the between\u2010group difference in 12\u2010month LAVI change (control\u2013CPAP) was nonsignificant (mean difference, 0.5\u2009mL\/m\n                      <jats:sup>2<\/jats:sup>\n                      [95% CI, \u22123.2 to 4.1 mL\/m\n                      <jats:sup>2<\/jats:sup>\n                      ];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.804). A linear mixed\u2010effects model for LAVI revealed a significant group\u00d7time interaction (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.005). NT\u2010proBNP declined in the CPAP group (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.029) without between\u2010group differences. Among 63 participants who completed follow\u2010up, a significant quadratic interaction was observed, with a downward LAVI trajectory in the CPAP group and an upward trajectory in controls after 6\u2009months (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.020). A modified Rankin Scale of 0 at 12\u2009months was more frequent with CPAP (46.9% versus 22.6%;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.043).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">In participants with stroke and obstructive sleep apnea, CPAP did not significantly reduce 12\u2010month LAVI compared with control; however, LAVI trajectories diverged over time. Among those who completed follow\u2010up, complete neurologic recovery was more frequent with CPAP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Registration<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique Identifier: NCT04458779.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.126.050964","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:34:18Z","timestamp":1790310858000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Continuous Positive Airway Pressure on Left Atrial Volume Index in Patients With Stroke and Obstructive Sleep Apnea: A Randomized Trial"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7786-2394","authenticated-orcid":false,"given":"Chou\u2010Han","family":"Lin","sequence":"first","affiliation":[{"name":"Far Eastern Memorial Hospital","place":["New Taipei City, Taiwan"]},{"name":"Far Eastern Memorial Hospital","place":["New Taipei City, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan\u2010Hui","family":"Huang","sequence":"additional","affiliation":[{"name":"Far Eastern Memorial Hospital","place":["New Taipei City, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6255-3071","authenticated-orcid":false,"given":"Yu Cheng","family":"Chu","sequence":"additional","affiliation":[{"name":"Far Eastern Memorial Hospital","place":["New Taipei City, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2198-0821","authenticated-orcid":false,"given":"Yan\u2010Siang","family":"Huang","sequence":"additional","affiliation":[{"name":"Far Eastern Memorial Hospital","place":["New Taipei City, Taiwan"]},{"name":"Yuan Ze University","place":["Taoyuan City, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9539-5030","authenticated-orcid":false,"given":"Vai Hong","family":"Fong","sequence":"additional","affiliation":[{"name":"Far Eastern Memorial Hospital","place":["New Taipei City, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7577-3380","authenticated-orcid":false,"given":"Chih\u2010Wei","family":"Tang","sequence":"additional","affiliation":[{"name":"Far Eastern Memorial Hospital","place":["New Taipei City, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1520-1166","authenticated-orcid":false,"given":"Yen\u2010Wen","family":"Wu","sequence":"additional","affiliation":[{"name":"Far Eastern Memorial Hospital","place":["New Taipei City, Taiwan"]},{"name":"National Yang Ming Chao Tung University","place":["Taipei, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/17474930241308142"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000375"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043104"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25515"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00034410"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.597468"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.008841"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.15.1788"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(03)00943-4"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.03.062"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000421"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2022.04.015"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.92.4.835"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.008711"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-043595"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.10.003"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcha.2023.101320"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.5684"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.613273"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.15882"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-0966"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-015-1153-7"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.03.100"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2009.173625"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.12181"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.637611"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.5940"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.7034"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1212\/CPJ.0000000000000954"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsy001"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.030702"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1606599"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01526-2019"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.16303"}],"container-title":["Journal 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