{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T14:30:28Z","timestamp":1793802628276,"version":"4.6.1"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"20","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,10,20]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Cardiac reverse remodeling and associated clinical outcomes following angiotensin receptor\u2010neprilysin inhibitor (ARNI) therapy in patients with heart failure (HF) with reduced ejection fraction (EF) remain unclear. We investigated differences in 1\u2010year echocardiographic response after ARNI therapy and predictors of clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">This study involved patients with HF with reduced EF and ARNI therapy for more than 6\u2009months, using data from a 2\u2010center registry. Echocardiographic data were analyzed at baseline and 1\u2009year after ARNI initiation. Responders were defined as patients with a \u226530% reduction in left ventricular end\u2010systolic volume at 1\u2009year; all others were nonresponders. The primary outcome was cardiovascular death, and secondary outcomes were hospitalization for HF and all\u2010cause death. Time\u2010by\u2010group interactions in echocardiographic parameters were evaluated using linear mixed\u2010effects models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Among 1002 patients (mean age: 64.2\u00b113.7\u2009years; 70.8% men), 451 (45.0%) were responders and 551 (55.0%) were nonresponders. Responders had a lower baseline left ventricular EF but higher left ventricular EF at 1\u2009year (27.0% [95% CI, 22.0\u201333.0] and 48.0% [95% CI, 42.0\u201355.0]). Both groups showed improvements in diastolic parameters, with more pronounced changes in responders. In multivariable analysis, nonresponders had a significantly higher risk of cardiovascular death, hospitalization for HF, and all\u2010cause death (all\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001). Male sex and a higher baseline left ventricular EF were independent predictors of nonresponse, whereas systolic blood pressure \u2265110\n                      <jats:styled-content style=\"fixed-case\" toggle=\"no\">mm\u2009Hg<\/jats:styled-content>\n                      and atrial fibrillation were associated with better outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Cardiac reverse remodeling after ARNI therapy varies among patients with HF with reduced EF. Positive responders to ARNI therapy at 1\u2009year experienced more favorable clinical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.126.051306","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T11:49:50Z","timestamp":1791632990000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Cardiac Reverse Remodeling and Clinical Outcomes Following Angiotensin Receptor\u2010Neprilysin Inhibitor Therapy in Heart Failure With Reduced Ejection Fraction"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7443-1132","authenticated-orcid":false,"given":"Nan Young","family":"Bae","sequence":"first","affiliation":[{"name":"Seoul National University Hospital","place":["Seoul, Republic of Korea"]},{"name":"Seoul National University College of Medicine","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1798-7441","authenticated-orcid":false,"given":"Soongu","family":"Kwak","sequence":"additional","affiliation":[{"name":"Seoul National University Hospital","place":["Seoul, Republic of Korea"]},{"name":"Seoul National University College of Medicine","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1717-6662","authenticated-orcid":false,"given":"Chan Soon","family":"Park","sequence":"additional","affiliation":[{"name":"Seoul National University Hospital","place":["Seoul, Republic of Korea"]},{"name":"Seoul National University College of Medicine","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6924-7106","authenticated-orcid":false,"given":"Jiesuck","family":"Park","sequence":"additional","affiliation":[{"name":"Seoul National University College of Medicine","place":["Seoul, Republic of Korea"]},{"name":"Seoul National University Bundang Hospital","place":["Seongnam\u2010si, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6856-2486","authenticated-orcid":false,"given":"Hong\u2010Mi","family":"Choi","sequence":"additional","affiliation":[{"name":"Seoul National University College of Medicine","place":["Seoul, Republic of Korea"]},{"name":"Seoul National University Bundang Hospital","place":["Seongnam\u2010si, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8479-9889","authenticated-orcid":false,"given":"Yeonyee E.","family":"Yoon","sequence":"additional","affiliation":[{"name":"Seoul National University College of Medicine","place":["Seoul, Republic of Korea"]},{"name":"Seoul National University Bundang Hospital","place":["Seongnam\u2010si, Republic of 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Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5502-3977","authenticated-orcid":false,"given":"Seung\u2010Pyo","family":"Lee","sequence":"additional","affiliation":[{"name":"Seoul National University Hospital","place":["Seoul, Republic of Korea"]},{"name":"Seoul National University College of Medicine","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4966-3924","authenticated-orcid":false,"given":"In\u2010Chang","family":"Hwang","sequence":"additional","affiliation":[{"name":"Seoul National University College of Medicine","place":["Seoul, Republic of Korea"]},{"name":"Seoul National University Bundang Hospital","place":["Seongnam\u2010si, Republic of 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