{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T05:04:56Z","timestamp":1789535096344,"version":"build-2803163510"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"18","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,9,15]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Studies suggest that hypoperfusion from heart failure (HF) may contribute to cognitive decline. However, the relationship between the HF subtypes and cognition remains poorly described in real\u2010world populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We conducted a cross\u2010sectional study of patients aged \u226518\u2009years seen at the Mayo Clinic in 2022 who underwent echocardiogram and cognitive assessment within 1\u2009year. HF was classified per the 2022 American Heart Association as no HF, HF with preserved ejection fraction (EF), HF with mildly reduced EF, and HF with reduced EF. Cognitive impairment was categorized using the Montreal Cognitive Assessment score as normal (\u226526), mild (18\u201325), and moderate to severe (&lt;18). Linear regression assessed EF\u2013Montreal Cognitive Assessment correlation and logistic regression the association between HF subtypes and cognitive dysfunction, adjusting for age, sex, race, and vascular risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      A total of 1592 patients met inclusion criteria (mean age, 75.7\u00b113.8\u2009years; 48.5% women). Lower EF was associated with worse cognitive performance (postadjustment \u03b2=0.033,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.013). Patients with HF with reduced EF and patients with HF with preserved EF had significantly lower Montreal Cognitive Assessment scores than those without HF (17.6\u00b16.2 and 18.9\u00b15.8 versus 19.9\u00b16.0,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001). The prevalence of moderate to severe cognitive impairment was highest in HF with reduced EF (43.3%), followed by HF with preserved EF (34.4%), no heart failure (28.6%), and HF with mildly reduced EF (23.4%) (adjusted trend\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.032).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">HF, independent of ejection fraction alone, is associated with cognitive impairment. Further studies should confirm these findings and evaluate the impact of interventions targeting EF and HF subtypes on cognitive outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.126.051559","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T14:53:31Z","timestamp":1788965611000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Cognition and Heart Failure Subtypes: A Large Health Care System Real\u2010World Cohort"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7302-2348","authenticated-orcid":false,"given":"Nihal","family":"Satyadev","sequence":"first","affiliation":[{"name":"Mayo Clinic in Florida","place":["Jacksonville, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iryna","family":"Lasiichuk","sequence":"additional","affiliation":[{"name":"Mayo Clinic in Florida","place":["Jacksonville, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4340-3849","authenticated-orcid":false,"given":"Md Manjurul Islam","family":"Shourav","sequence":"additional","affiliation":[{"name":"Mayo Clinic in Florida","place":["Jacksonville, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4564-6503","authenticated-orcid":false,"given":"Saikrishna","family":"Vallamchetla","sequence":"additional","affiliation":[{"name":"Mayo Clinic in Florida","place":["Jacksonville, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin","family":"McGrath","sequence":"additional","affiliation":[{"name":"Mayo Clinic in Florida","place":["Jacksonville, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0844-613X","authenticated-orcid":false,"given":"Michael Acevedo","family":"Monsanto","sequence":"additional","affiliation":[{"name":"Mayo Clinic in Florida","place":["Jacksonville, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8629-2029","authenticated-orcid":false,"given":"Demilade","family":"Adedinsewo","sequence":"additional","affiliation":[{"name":"Mayo Clinic in Florida","place":["Jacksonville, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4475-8142","authenticated-orcid":false,"given":"James F.","family":"Meschia","sequence":"additional","affiliation":[{"name":"Mayo Clinic in Florida","place":["Jacksonville, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0219-027X","authenticated-orcid":false,"given":"Michelle P.","family":"Lin","sequence":"additional","affiliation":[{"name":"Mayo Clinic in Florida","place":["Jacksonville, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001063"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001123"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000476"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.63.4.509"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2012-301682"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfq042"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-018-4556-x"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfr055"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000013249"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/725353"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad655.935"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53221.x"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)61905-3"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3181577654"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.70291"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2019.01.043"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.117.004476"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/JCN.0000000000000711"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.01.022"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2023.1181979"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-023-01938-w"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/eci.70008"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.126.051559","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T04:35:19Z","timestamp":1789533319000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.126.051559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,15]]},"references-count":22,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2026,9,15]]}},"alternative-id":["10.1161\/JAHA.126.051559"],"URL":"https:\/\/doi.org\/10.1161\/jaha.126.051559","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,15]]},"assertion":[{"value":"2026-04-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e051559"}}